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    Oxybutynin chloride
    Oxybutynin chloride

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1193
    CAS #: 1508-65-2Purity ≥98%

    Description: Oxybutynin chloride (Ditropan; Ditropan XL), the hydrochloride salt of oxybutynin, is a competitive antagonist of muscarinic acetylcholine receptor subtypes M1, M2, and M3 used to treat bladder and urinary conditions (i.e. overactive bladder, urinary and bladder difficulties).  

    References: Pharmacol Toxicol. 1998 Apr;82(4):161-6; Life Sci. 2010 Jul 31;87(5-6):175-80.

    Related CAS #: 5633-20-5 (free)   1508-65-2 (HCl)  

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    Molecular Weight (MW)393.95
    FormulaC22H31NO3.HCl
    CAS No.1508-65-2
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 79 mg/mL (200.5 mM)
    Water: 4 mg/mL (10.15 mM)
    Ethanol: 79 mg/mL (200.5 mM)
    Other info

    Chemical Name: 4-Diethylaminobut-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylethanoate Hydrochloride

    InChi Key: SWIJYDAEGSIQPZ-UHFFFAOYSA-N

    InChi Code: InChI=1S/C22H31NO3.ClH/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20;/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3;1H

    SMILES Code: O=C(OCC#CCN(CC)CC)C(O)(C1CCCCC1)C2=CC=CC=C2.[H]Cl

    Synonyms

    Oxybutynin hydrochloride; Oxybutynin HCl


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    In Vitro

    In vitro activity: Oxybutynin N-deethylation in human liver microsomes in vitro is potently inhibited by ketoconazole (IC50 4.5 mM), less and variably by itraconazole and not by quinidine or several other reference inhibitors, suggesting that CYP3A enzymes are predominant catalysts of the reaction. Oxybutynin inhibits CYP3A4- and CYP2D6- associated activities (testosterone 6 beta-hydroxylase and dextromethorphan O- demethylase, respectively) in human liver microsomes. Oxybutynin is predominantly metabolized by CYP3A4 and CYP3A5 but not by CYP2D6. Oxybutynin (30, 100 nM) competitively antagonizes acetylcholine-induced contractions but does not alter those induced by histamine. Oxybutynin (up to 10 mM) induces a non-competitive depression of responses to both agonists and causes a parallel shift to the right of the Ca2+-induced contractions in taenia caeci strips bathed in a Ca2+-free, high-K+ medium. Oxybutynin (1-10 mM) impairs rhythmic muscular contractions in normal medium and after CaCl2 addition in Ca2+-free medium. Oxybutynin increases the perfusion pressure starting at 100 mM in perfused rat liver. Oxybutynin also increases the perfusion pressure in the hepatic artery.

    In VivoOxybutynin decreases significantly binding potential (BP) of (+)N-[(11)C]methyl-3-piperidyl benzilate ([(11)C](+)3-MPB) in the rat cerebral cortex and corpus striatum in a dose-dependent manner. Oxybutynin induces a significant decrease in micturition pressure without changes in BVC in obstructed rats. 
    Animal modelRats
    Formulation & DosageN/A
    References

    Pharmacol Toxicol. 1998 Apr;82(4):161-6; Life Sci. 2010 Jul 31;87(5-6):175-80. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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