| Size | Price | Stock | Qty |
|---|---|---|---|
| 10mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
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| ln Vitro |
Oxyconazole (24 hours; 0-40 μM) suppresses the development of CRC cells [3]. Trichophyton, Aspergillus, and Candida are susceptible to the antifungal effects of oxyconazole [1]. Oxyconazole's antifungal activity [1]. Candida albicans Candida pneumonia Porphyromonas fumigatus Aspergillus flavus Mentagrophytes Trichophyton Rubrum Trichophyton oxyconazole A 0.03 μg/mL, a 0.01 μg/mL, and a 0.008 μg/mL, two μg/mL, two μg/mL, and two μg/mL
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|---|---|
| ln Vivo |
For 12 days, oxyconazole (50 mg/kg/day; IP) dramatically reduces the development of colorectal cancer cells [3].
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| Cell Assay |
Cell Proliferation Assay[3]
Cell Types: HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 Tested Concentrations: 0-40 μM Incubation Duration: 24 hrs (hours) Experimental Results: For HCT116, SW480, RKO, DLD -1, SW620, LoVo and NCM460 demonstrated inhibitory activity IC50 of 25.86 μM, 27.34 μM, 21.01 μM, 25.56 μM, 21.75 μM, 24.87 μM and 126.4 μM. |
| Animal Protocol |
Animal/Disease Models: BALB/c nude mice (subcutaneous injection of HCT116 cells (1×107/mouse) [3]
Doses: 50 mg/kg/day Route of Administration: IP; 12 days. Experimental Results: Dramatically inhibited CRC cell growth, and No obvious side effects. |
| References |
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| Additional Infomation |
Oxiconazole nitrate is an organic nitrate salt resulting from the reaction of equimolar amounts of oxiconazole and nitric acid. An antifungal agent, it is used in creams and powders for the topical treatment of fungal skin infections. It has a role as an antiinfective agent. It is an organic nitrate salt, a conazole antifungal drug and an imidazole antifungal drug. It contains an oxiconazole(1+).
Oxiconazole Nitrate is the nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth. See also: Oxiconazole (has active moiety). |
| Molecular Formula |
C18H13CL4N3O.HNO3
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|---|---|
| Molecular Weight |
492.14
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| Exact Mass |
491.973
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| CAS # |
64211-46-7
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| Related CAS # |
Oxiconazole;64211-45-6
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| PubChem CID |
9556529
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| Appearance |
White to off-white solid powder
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| Boiling Point |
576.8ºC
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| Melting Point |
137-1380C
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| Flash Point |
302.6ºC
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| LogP |
6.155
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| Hydrogen Bond Donor Count |
1
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
30
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| Complexity |
506
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| Defined Atom Stereocenter Count |
0
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| SMILES |
C1=CC(=C(C=C1Cl)Cl)CO/N=C(\CN2C=CN=C2)/C3=C(C=C(C=C3)Cl)Cl.[N+](=O)(O)[O-]
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| InChi Key |
WVNOAGNOIPTWPT-NDUABGMUSA-N
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| InChi Code |
InChI=1S/C18H13Cl4N3O.HNO3/c19-13-2-1-12(16(21)7-13)10-26-24-18(9-25-6-5-23-11-25)15-4-3-14(20)8-17(15)22;2-1(3)4/h1-8,11H,9-10H2;(H,2,3,4)/b24-18+;
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| Chemical Name |
(Z)-1-(2,4-dichlorophenyl)-N-[(2,4-dichlorophenyl)methoxy]-2-imidazol-1-ylethanimine;nitric acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ≥ 100 mg/mL (~203.19 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (5.08 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (5.08 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (5.08 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0319 mL | 10.1597 mL | 20.3194 mL | |
| 5 mM | 0.4064 mL | 2.0319 mL | 4.0639 mL | |
| 10 mM | 0.2032 mL | 1.0160 mL | 2.0319 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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