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    Otilonium Bromide (Octylonium bromide; SP63)
    Otilonium Bromide  (Octylonium bromide; SP63)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1192
    CAS #: 26095-59-0 Purity ≥98%

    Description: Otilonium bromide (SP-63; Octylonium bromide; SP63; trade name Spasmomen among others) is a potent anti-muscarinic agent and a CCB (calcium channel blocker) used to relieve spasmodic pain of the gut, in particular in irritable bowel syndrome. Otilonium bromide is a quaternary ammonium compound whose spasmolytic action, selective on the distal gastrointestinal tract, is mainly due to its direct myolytic properties. This drug modifies Ca2+ fluxes from extracellular and intracellular pools in the intestinal smooth muscle and is poorly absorbed, thus it exerts its action locally, without any considerable systemic effect.

    References: Arch Int Pharmacodyn Ther. 1983 Aug;264(2):305-23; Aliment Pharmacol Ther. 1998 Oct;12(10):1003-10.

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    Molecular Weight (MW)563.57 
    FormulaC29H43BrN2O4 
    CAS No.26095-59-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 113 mg/mL (200.5 mM) 
    Water: 113 mg/mL (200.5 mM)
    Ethanol: 113 mg/mL (200.5 mM) 
    SMILESO=C(OCC[N+](CC)(CC)C)C1=CC=C(NC(C2=CC=CC=C2OCCCCCCCC)=O)C=C1.[Br-]
    SynonymsSP-63; Octylonium bromide; SP 63; SP63; 


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    In Vitro

    In vitro activity: Otilonium bromide is a quaternary ammonium compound whose spasmolytic action, selective on the distal gastrointestinal tract, is mainly due to its direct myolytic properties. This drug modifies Ca2+ fluxes from extracellular and intracellular pools in the intestinal smooth muscle and is poorly absorbed, thus it exerts its action locally, without any considerable systemic effect.

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    References

    Arch Int Pharmacodyn Ther. 1983 Aug;264(2):305-23; Aliment Pharmacol Ther. 1998 Oct;12(10):1003-10. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Otilonium Bromide
    Mean (± s.d.) modifications in the score for frequency (A) and intensity (B) of abdominal pain in otilonium bromide and placebo treated patients. Aliment Pharmacol Ther. 1998 Oct;12(10):1003-10.
     
    Otilonium Bromide
    Mean (± s.d.) modifications in the global score for abdominal pain in otilonium bromide and placebo treated patients. Aliment Pharmacol Ther. 1998 Oct;12(10):1003-10.
     
    Otilonium Bromide
    Frequency of efficacy judgements (good or excellent) expressed by the investigators in otilonium bromide and placebo treated patients. Aliment Pharmacol Ther. 1998 Oct;12(10):1003-10.


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