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    Omecamtiv mecarbil
    Omecamtiv mecarbil

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0063
    CAS #: 873697-71-3Purity ≥98%

    Description: Omecamtiv mecarbil (also known as CK-1827452) is a specific cardiac myosin activator and a clinical drug for left ventricular systolic heart failure. Omecamtiv mecarbil is clinically investigated for its role in the treatment of left ventricular systolic heart failure. It specifically targets and activates myocardial ATPase and improves energy utilization. Omecamtiv Mecarbil improves systolic function by increasing the systolic ejection duration/stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency. 

    References: Circ Heart Fail. 2010 Jul;3(4):522-7.

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    Molecular Weight (MW)401.43
    FormulaC20H24FN5O3 
    CAS No.873697-71-3
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 80 mg/mL (199.3 mM)
    Water: <1 mg/mL
    Ethanol: 6 mg/mL (14.9 mM)
    Solubility (In vivo)1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL 
    Synonyms


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    In Vitro

    In vitro activity: In vitro, Omecamtiv mecarbil selectively activates cardiac myosin by increasing the myosin ATPase rate. In isolated cardiac myocytes, Omecamtiv mecarbil results in increase of myocyte contractility and overcomes of the myosin inhibitor BDM without increasing the calcium transient or inhibiting the PDE pathway.


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    Cell Assay: 

    In VivoOmecamtiv mecarbil significantly increases fractional shortening starting at 0.4 mM plasma concentrations in SD rats, sham animals and in rats with heart failure. In conscious dogs with myocardial infarction (MI-sHF), Omecamtiv mecarbil leads to a significant increase in wall thickening (25%), stroke volume (44%), cardiac output (22%) and left ventricular (LV) systolic ejection time (26%). In addition, Omecamtiv mecarbil also results in the decreases of some hemodynamic parameters including heart rate, mean left atrial pressure, and LV end-diastolic pressure. In conscious dogs with left ventricular hypertrophy (LVH-sHF), Omecamtiv mecarbil leads to similar and not statistically different effects on hemodynamic parameters.
    Animal modelSprague Dawley rats.
    Formulation & DosageDissolved in DMSO and then diluted in water; ≤1.2 mg/kg/hour; i.v. injection.
    References

    Circ Heart Fail. 2010 Jul;3(4):522-7.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Omecamtiv mecarbil




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