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    Nobiletin
    Nobiletin

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0738
    CAS #: 478-01-3Purity ≥98%

    Description: Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, has anti-inflammatory and anti-tumor activities. Nobiletin is able to suppress tumor growth, invasion, proliferation, and metastasis in vitro and in animal studies. Nobiletin was also found to potentially inhibit cartilage degradation. In human nasopharyngeal carcinoma cell lines (HONE-1 and NPC-BM), nobiletin treatment significantly inhibited cells invasion via inhibiting the phosphorylation of ERK1/2. When tested with rat C6 glioma cell, nobiletin was shown to inhibit cell proliferation via suppress ERK activity.

    References: Cancer Res. 2000 Sep 15;60(18):5059-66; Cancer Res. 2002 Feb 15;62(4):1025-9.

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    Molecular Weight (MW)402.39
    FormulaC21H22O8
    CAS No.478-01-3
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 81 mg/mL (201.3 mM)
    Water: <1 mg/mL
    Ethanol: 3 mg/mL (7.5 mM)
    SMILESO=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C1C(OC)=C(OC)C(OC)=C3OC
    SynonymsNobiletin; Hexamethoxyflavone; NOB; 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one 

    Chemical Name: 2-(3,4-Dimethoxyphenyl)-5,6,7,8-tetramethoxychromen-4-one

    InChi Key: MRIAQLRQZPPODS-UHFFFAOYSA-N

    InChi Code: InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3


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    In Vitro

    In vitro activity: Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, which has anti-inflammatory and anti-tumor activities. Nobiletin, a polymethoxyflavonoid, is identified as an inhibitor of both NO and O 2- generation. Nobiletin significantly inhibites two skin inflammation induced by double TPA application. It also suppresses the expression of cyclooxygenase-2 and inducible NO synthase proteins and prostaglandin E2 release. Nobiletin inhibites the tumor-invasive activity of human fibrosarcoma HT-1080 cells in the Matrigel model, not only by suppressing the expression of MMPs but also augmenting TIMP-1 production through interfering the phosphatidylinositol 3-kinase pathway (PI3-K). Nobiletin may also prevent atherosclerosis at the level of the vascular wall by inhibiting macrophage foam-cell formation.


    Kinase Assay: Nobiletin, a citrus flavonoid isolated from citrus peels like in tangerine, has anti-inflammatory and anti-tumor activities. Nobiletin is able to suppress tumor growth, invasion, proliferation, and metastasis in vitro and in animal studies. Nobiletin was also found to potentially inhibit cartilage degradation. In human nasopharyngeal carcinoma cell lines (HONE-1 and NPC-BM), nobiletin treatment significantly inhibited cells invasion via inhibiting the phosphorylation of ERK1/2. When tested with rat C6 glioma cell, nobiletin was shown to inhibit cell proliferation via suppress ERK activity.


    Cell Assay: Nobiletin is shown to have the ability to suppress tumor growth and metastasis. In human nasopharyngeal carcinoma cell lines (HONE-1 and NPC-BM), nobiletin treatment significantly inhibited cells invasion via inhibiting the phosphorylation of ERK1/2 [2]. When tested with rat C6 glioma cell, nobiletin was shown to inhibit cell proliferation via suppress ERK activity.

    In VivoIn mouse model with 5-min BCCAO-induced brain ischemia, treatment nobiletin (50 mg/kg) intraperitoneally for the consecutive 7 days significantly inhibited delayed neuronal death in the hippocampal CA1 neurons and improved contextual memory. In MPTP-induced Parkinson mouse model, administration of Nobiletin (50mg/kg i.p.) intraperitoneally for 2 consecutive weeks improved motor and cognitive deficits.
    Animal modelMouse
    Formulation & Dosage50 mg/kg; i.p. injection
    ReferencesCancer Res. 2000 Sep 15;60(18):5059-66; Cancer Res. 2002 Feb 15;62(4):1025-9.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

     

    Nobiletin

    Nobiletin suppresses tumor cell invasion in vitro.  Cancer Res. 2002 Feb 15;62(4):1025-9.
     

    Nobiletin

    Effect of nobiletin on the production of proMMPs and TIMP-1 in HT-1080 cells. Cancer Res. 2002 Feb 15;62(4):1025-9.
     

    Nobiletin

    Effect of nobiletin on the gene expression of proMMPs and TIMP-1 in HT-1080 cells. Cancer Res. 2002 Feb 15;62(4):1025-9.
     

    Nobiletin

    Nobiletin does not modify the expression of proMMP-2, MT1-MMP, and TIMP-2 in HT-1080 cells. Cancer Res. 2002 Feb 15;62(4):1025-9.
     

    Nobiletin

    Nobiletin inhibits AP-1 binding activity in HT-1080 cells. Cancer Res. 2002 Feb 15;62(4):1025-9.
     

    Nobiletin

    PI3K inhibitor, LY-294002, mimics the effect of nobiletin on proMMP-9 and TIMP-1 production in HT-1080 cells. Cancer Res. 2002 Feb 15;62(4):1025-9.


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