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      Nitenpyram
      Nitenpyram

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      This product is for research use only, not for human use. We do not sell to patients.
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      InvivoChem Cat #: V1166
      CAS #: 150824-47-8Purity ≥98%

      Description: Nitenpyram (trade names Capstar, Bestguard), an insect neurotoxin of the neonicotinoid class, is a fast and long-acting, and orally bioavailable nicotinic acetylcholine receptor (AchR) agonist with neural signaling-blocking activity. It has been widely used as a veterinary medication to treat adult flea infestations, also used to treat parasites of livestock and pets.  

      References: J Agric Food Chem. 2016 Dec 14;64(49):9276-9285.

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      Molecular Weight (MW)270.72
      FormulaC11H15ClN4O2
      CAS No.150824-47-8
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 54 mg/mL (199.5 mM)
      Water: N/A
      Ethanol: 54 mg/mL (199.5 mM)
      SMILESO=[N+](/C=C(NC)/N(CC1=CC=C(Cl)N=C1)CC)[O-]
      SynonymsNitenpyram; Capstar, Bestguard


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      In Vitro

      In vitro activity: Nitenpyram is a nicotinic acetylcholine receptor (AchR) agonist, used as veterinary medicine to treat parasites of livestock and pets. Nitenpyram is a new type of neonicotinoid insecticide with 2,2-bis(amino)nitroethene as the base structure, which has been developed by Takeda Pharmaceutical Company Limited.It is remarkably effective against pests of order Hemiptera, such as planthoppers, leafhoppers and aphids, and characterized by fast action, long lasting and systemic properties as well as safety for plants.

      In VivoNitenpyram is administered orally (1 mg/kg) for the short-term control of fleas in dogs and cats. Fleas start to fall from the animals 30 minutes post-administration and one dose can protect animals for 1-2 days.Since Nitenpyram is highly lipophilic, it is administered orally after the meal in order to induce bile flow to help dissolve the chemical, thereby increasing GI absorption of the drug. It is rapidly and completely absorbed from the GI tract in less than 90 minutes and is completely excreted in urine within 48 hours after oral administration to dogs and cats. Nitenpyram undergoes hydroxylation, followed by conjugation in the liver. The conjugates of Nitenpyram are excreted in the urine and Nitenpyram is not accumulated in body tissues. The plasma half-life of Nitenpyram in dogs and cats are 3 and 8 hours, respectively. It is likely that animals with liver and/or kidney problems may have longer plasma half-life of Nitenpyram
      Animal modelDogs and cats
      Formulation & Dosage1 mg/kg; oral
      References

      [1]. Vo DT, et al. Insect nicotinic acetylcholine receptor agonists as flea adulticides in small animals. J Vet Pharmacol Ther. 2010 Aug;33(4):315-22.

      [2]. Rust MK, et al. Efficacy and longevity of nitenpyram against adult cat fleas (Siphonaptera: Pulicidae). J Med Entomol. 2003 Sep;40(5):678-81.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

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