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    Nicardipine HCl (RS69216; YC93; Antagonil, Dagan, Flusemide)
    Nicardipine HCl (RS69216; YC93; Antagonil, Dagan, Flusemide)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0748
    CAS #: 54527-84-3 Purity ≥98%

    Description: Nicardipine HCl (formerly YC-93, RS-69216; YC93; trade names Cardene, Dagan, Antagonil, Flusemide), the hydrochloride salt of nicardipine, is a dihydropyridine/DHP class of calcium-channel blocker (CCB) with anti-hypertensive activity. It has been approved for use in the treatment of high blood pressure, angina, chronic stable angina and Raynaud's phenomenon. 

    References: Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2885-90; J Hypertens Suppl. 1996 Oct;14(3):S29-35.

    Related CAS: 55985-32-5  (free base)

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    Molecular Weight (MW)515.99 
    FormulaC26H29N3O6.HCl 
    CAS No.54527-84-3 (HCl); 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (193.8 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info
    Chemical Name: 2-(Benzylmethylamino)ethyl methyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylatemonohydrochloride
    InChi Key: AIKVCUNQWYTVTO-UHFFFAOYSA-N
    InChi Code: InChI=1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H
    SMILES Code: CC1=C(C(C(=C(N1)C)C(=O)OCCN(C)Cc2ccccc2)c3cccc(c3)[N+](=O)[O-])C(=O)OC.Cl 
    SynonymsNicardipine HCl; YC 93; YC93; Cardene, RS69216; Nicardipine Hydrochloride; RS-69216; RS 69216; YC-93; Antagonil, Dagan, Flusemide


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    In Vitro

    In vitro activity: Nicardipine HCl (also known as YC-93 HCL, and trade names: Cardene, Antagonil, Dagan, Flusemide)  is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as high blood pressure, angina, chronic stable angina and Raynaud's phenomenon. Nicardipine hydrochloride is the hydrochloride salt form of Nicardipine and a potent L-type calcium channel protein inhibitor. It is described to alter cytochrome P-450 3A expression through induction of CYP3A. Nicardipine blockade of Ca2+ channels has been correlated to antihypertensive effects.

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    ReferencesInvest Ophthalmol Vis Sci. 1992 Sep;33(10):2885-90; J Hypertens Suppl. 1996 Oct;14(3):S29-35.




    These protocols are for reference only. InvivoChem does not independently validate these methods.

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