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    Mometasone furoate
    Mometasone furoate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1701
    CAS #: 83919-23-7Purity ≥98%

    Description: Mometasone Furoate (formerly Sch 32088; Sch32088; SCH-32088) is a potent glucocorticoid receptor agonist and an approved anti-inflammatory drug used as a topical formulation to reduce inflammation of the skin or in the airways. As a topical corticosteroid, mometasone furoate has anti-inflammatory, antipruritic, and vasoconstrictive properties. 

    References: Immunopharmacol Immunotoxicol. 2006;28(3):491-500; Eur J Pharmacol. 2005 Nov 7;524(1-3):155-8.


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    Molecular Weight (MW)521.43
    FormulaC27H30Cl2O6
    CAS No.83919-23-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 6 mg/mL (11.5 mM)
    Water:<1 mg/mL
    Ethanol:<1 mg/mL
    Other infoChemical Name: (8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
    InChi Key: WOFMFGQZHJDGCX-ZULDAHANSA-N
    InChi Code: InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
    SMILES Code: O=C(C1=CC=CO1)O[[email protected]]2(C(CCl)=O)[[email protected]](C)C[[email protected]@]3([H])[[email protected]]4([H])CCC5=CC(C=C[[email protected]]5(C)[[email protected]@]4(Cl)[[email protected]@H](O)C[[email protected]]23C)=O
    SynonymsSCH-32088; Sch 32088; mometasone furoate cream (0.1); Sch-32088; Sch32088; 


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    In Vitro

    In vitro activity: Mometasone furoate efficiently suppresses production of cytokines including interleukin (IL)-4, IL-5, and interferon-gamma in anti-CD3-stimulated human CD4+ T cells. Mometasone furoate effectively inhibits the activation of Th cells including type 2 Th (Th2) in the draining LN, thus leading to the suppression of the IgE response.


    Kinase Assay: Mometasone furoate, prodrug of the free form mometasone, is a agent with high affinity for the glucocorticoid receptor. IC50 value: Target: glucocorticosteroid receptor Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma.

    In VivoMometasone causes a decrease in the instances of nasal rubbing and an inhibition of this response is observed during the treatment period in rats. Mometasone (3 mg/kg) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested in mice. Mometasone, given an hour after the last allergen challenge, dose-dependently inhibits the allergen-induced increase in Penh with about a 10-fold loss of potency when compared with the pre-challenge treatment schedule. Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibits the increase of antigen-induced nasal rubbing even 6 hours after topical application, indicating that both drugs have a long-lasting effect. Mometasone furoate dose-dependently inhibits the elevated eosinophil numbers in the bronchoalveolar lavage fluid and lung tissues of sensitized, ovalbumin challenged mice. Mometasone furoate (33 mg/kg) reduces the percentage of CD44+ T-helper cells (activated/memory cells) to the levels observed in non-sensitized, ovalbumin-challenged mice.
    Animal modelovalbumin-challenged mice
    Formulation & Dosage3 mg/kg
    ReferencesImmunopharmacol Immunotoxicol. 2006;28(3):491-500; Eur J Pharmacol. 2005 Nov 7;524(1-3):155-8.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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