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    Mometasone furoate
    Mometasone furoate

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1701
    CAS #: 83919-23-7Purity ≥98%

    Description: Mometasone Furoate (formerly also known as SCH-32088) is a potent glucocorticoid receptor agonist used topically to reduce inflammation of the skin or in the airways. Like other topical corticosteroids, mometasone furoate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti- inflammatory activity of the topical steroids remains unclear. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2. The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle and the integrity of the epidermal barrier.  

    References: Immunopharmacol Immunotoxicol. 2006;28(3):491-500; Eur J Pharmacol. 2005 Nov 7;524(1-3):155-8.

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    Molecular Weight (MW)521.43
    CAS No.83919-23-7
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 6 mg/mL (11.5 mM)
    Water:<1 mg/mL
    Ethanol:<1 mg/mL
    Other infoChemical Name: (8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-17-(2-chloroacetyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl furan-2-carboxylate
    InChi Code: InChI=1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
    SMILES Code: O=C(C1=CC=CO1)O[[email protected]]2(C(CCl)=O)[[email protected]](C)C[[email protected]@]3([H])[[email protected]]4([H])CCC5=CC(C=C[[email protected]]5(C)[[email protected]@]4(Cl)[[email protected]@H](O)C[[email protected]]23C)=O
    SynonymsSCH-32088; Sch-32088; Sch32088; Sch 32088; ELOCON brand of mometasone furoate cream (0.1)

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    In Vitro

    In vitro activity: Mometasone furoate efficiently suppresses production of cytokines including interleukin (IL)-4, IL-5, and interferon-gamma in anti-CD3-stimulated human CD4+ T cells. Mometasone furoate effectively inhibits the activation of Th cells including type 2 Th (Th2) in the draining LN, thus leading to the suppression of the IgE response.

    Kinase Assay: Mometasone furoate, prodrug of the free form mometasone, is a agent with high affinity for the glucocorticoid receptor. IC50 value: Target: glucocorticosteroid receptor Mometasone furoate is used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), asthma.

    In VivoMometasone causes a decrease in the instances of nasal rubbing and an inhibition of this response is observed during the treatment period in rats. Mometasone (3 mg/kg) inhibits the increased airway sensitivity to aerosolized methacholine at the highest dose tested in mice. Mometasone, given an hour after the last allergen challenge, dose-dependently inhibits the allergen-induced increase in Penh with about a 10-fold loss of potency when compared with the pre-challenge treatment schedule. Mometasone furoate (0.02%) and fluticasone propionate (0.1%) significantly inhibits the increase of antigen-induced nasal rubbing even 6 hours after topical application, indicating that both drugs have a long-lasting effect. Mometasone furoate dose-dependently inhibits the elevated eosinophil numbers in the bronchoalveolar lavage fluid and lung tissues of sensitized, ovalbumin challenged mice. Mometasone furoate (33 mg/kg) reduces the percentage of CD44+ T-helper cells (activated/memory cells) to the levels observed in non-sensitized, ovalbumin-challenged mice.
    Animal modelovalbumin-challenged mice
    Formulation & Dosage3 mg/kg
    ReferencesImmunopharmacol Immunotoxicol. 2006;28(3):491-500; Eur J Pharmacol. 2005 Nov 7;524(1-3):155-8.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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