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    Mitiglinide Calcium (KAD-1229)
    Mitiglinide Calcium (KAD-1229)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1679
    CAS #: 145525-41-3 Purity ≥98%

    Description: Mitiglinide Calcium, the calcium salt of Mitiglinide (also known as KAD-1229; S21403), is a Potassiun Channel blocker that is used as a blood glucose-lowering drug, it stimulates insulin secretion by closing the ATP-sensitive K+ channels in pancreatic beta-cells. Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) K(ATP) channels in pancreatic beta-cells. Mitiglinide may be potential useful for the treatment of type 2 diabetes. 

    References:  Endocr J. 2015;62(12):1049-57; BMJ Open Diabetes Res Care. 2015 Aug 28;3(1):e000122.

    Related CAS#: 0145375-43-5 (Mitiglinide)

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    Molecular Weight (MW)668.88
    Formula(C19H24NO3)2.Ca
    CAS No.145525-41-3 (Mitiglinide Calcium)
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL
    Water:<1 mg/mL
    Ethanol: 2 mg/mL (2.99 mM)
    SMILES Code O=C([O-])C(CC1=CC=CC=C1)CC(N2C[[email protected]]3([H])CCCC[[email protected]]3([H])C2)=O.O=C([O-])C(CC4=CC=CC=C4)


    CC(N5C[[email protected]]6([H])CCCC[[email protected]]6([H])C5)=O.[Ca+2]

    SynonymsKAD-1229; KAD 1229; KAD1229; S 21403; Mitiglinide calcium; Glufast.


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    In Vitro

    In vitro activity: Mitiglinide (KAD-1229; S21403) is a drug for the treatment of type 2 diabetes; it is a highly selective KATP channel antagonist. IC50 value: Target: KATP channel Mitiglinide is a hypoglycemic agent that closes adenosine triphosphate (ATP)-sensitive potassium channels (KATP channel s) in the pancreatic β-islet cells. Mitiglinide stimulates insulin secretion by stimulating Ca2+ influx.

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    These protocols are for reference only. InvivoChem does not independently validate these methods.

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