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    MHY1485
    MHY1485

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0209
    CAS #: 326914-06-1Purity ≥98%

    Description: MHY1485 (MHY-1485) is a novel, potent and cell-permeable activator of mTOR (mammalian target of rapamycin) and an inhibitor of autophagy that suppress the fusion between autophagosomes and lysosomes.

    References:PLoS One. 2012;7(8):e43418; PLoS One. 2015; 10(2): e0117769.   

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    Molecular Weight (MW)

    387.39

    Formula

    C17H21N7O4

    CAS No.

    326914-06-1

    Storage

    -20℃ for 3 years in powder form

    -80℃ for 2 years in solvent

    Solubility (In vitro)

    DMSO: 33 mg/mL (85.2 mM)

    Water: <1 mg/mL

    Ethanol: <1 mg/mL

    Other info

    Chemical Name: 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

    InChi Key: MSSXBKQZZINCRI-UHFFFAOYSA-N

    InChi Code: InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)

    SMILES Code: O=[N+](C1=CC=C(NC2=NC(N3CCOCC3)=NC(N4CCOCC4)=N2)C=C1)[O-]

    Synonyms

    MHY-1485; MHY 1485; MHY1485


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    In Vitro

    In Vitro activity: MHY1485 suppresses the basal autophagic flux. MHY1485 causes the accumulation of LC3II and enlargement of the autophagosomes in a dose- and time- dependent manner. MHY1485 increases phospho-mTOR levels and phosphorylation of downstream S6K1 and rpS6 proteins without affecting total mTOR content, total S6K1 and rpS6 levels. Short-term treatment of ovaries with MHY1485 followed by allo-transplantation promoted secondary follicle growth. Treatment with MHY1485 and subsequent grafting allowed the derivation of mature oocytes and healthy offspring.

      

    Cell Assay: MHY1485 (10 μM; 4 hours) shows that GCDC-induced autophagic activity is s inhibited by upregulating p-mTOR expression and downregulating LC3 and p62 expression in HCC cells. MHY1485 (5 μM; 6 hours) increases the LC3II/LC3I ratio in a dose and time-dependently manner due to presumably inhibited LC3II degradation in rat liver Ac2F cells. MHY1485 (0.5-2 μM; 6 hours) increases the phosphorylation of mTOR at ser2448 and upregulates the level of phosphorylation of 4E-BP1 in a dose-dependently manner in Ac2F cells.

    In Vivo

    N/A

    Animal model

    N/A

    Formulation & Dosage

    N/A

    References

    PLoS One. 2012;7(8):e43418; PLoS One. 2015; 10(2): e0117769.   


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    MHY1485

    Failure of the increase of autophagic flux. PLoS One. 2012; 7(8): e43418.

    MHY1485

    Inhibition of starvation-induced autophagic flux by MHY1485.

    MHY1485

    Activation of mTOR by MHY1485.


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