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Methoxsalen (8-Methoxypsoralen) is a naturally occurring chemical substance extracted from the seeds of the plant Ammi majus with photoactivating properties. It is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. As a member of the family of compounds known as psorally bioavailableens or furocoumarins, methoxsalen's exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA.
| ln Vivo |
Methoxsalen (15 mg/kg, i.p., single dosage) raises the Cmax and AUC of nicotine while prolonging its half-life (by four times) and decreasing its clearance (by six times) [1].
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| Animal Protocol |
Animal/Disease Models: Male adult ICR mice [1]
Doses: 15 mg/kg Route of Administration: intraperitoneal (ip) injection, single dose Experimental Results: nicotine plasma concentration is still higher than 10ng/ml at 6 hrs (hrs (hours)). The analgesic and cooling effects of induced nicotine lasted for nearly 6 hrs (hrs (hours)) and 24 hrs (hrs (hours)). |
| References |
[1]. Alsharari SD, et al. Pharmacokinetic and Pharmacodynamics Studies of Nicotine After Oral Administration in Mice: Effects of Methoxsalen, a CYP2A5/6 Inhibitor. Nicotine Tob Res. 2014 Jan;16(1):18-25.
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| Molecular Formula |
C12H8O4
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| Molecular Weight |
216.1895
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| CAS # |
298-81-7
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| Related CAS # |
Methoxsalen-d3;80386-99-8
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| SMILES |
O1C([H])=C([H])C2C([H])=C3C([H])=C([H])C(=O)OC3=C(C1=2)OC([H])([H])[H]
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~50 mg/mL (~231.28 mM)
H2O : ~0.67 mg/mL (~3.10 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (11.56 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (11.56 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.6256 mL | 23.1278 mL | 46.2556 mL | |
| 5 mM | 0.9251 mL | 4.6256 mL | 9.2511 mL | |
| 10 mM | 0.4626 mL | 2.3128 mL | 4.6256 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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