| Size | Price | Stock | Qty |
|---|---|---|---|
| 5mg |
|
||
| 10mg |
|
||
| 25mg |
|
||
| 50mg |
|
||
| Other Sizes |
| References |
|
|---|---|
| Additional Infomation |
Meta-fexofenadine (also known as impurity B) is one of several related compounds (impurities) that may be present with the active pharmaceutical ingredient fexofenadine hydrochloride (FEX). [1] It is the meta-isomer of fexofenadine. [1] The British Pharmacopoeia (BP) lists it as one of the four major impurities of FEX and specifies a separate high-performance liquid chromatography (HPLC) method for detection using a β-cyclodextrin-modified silica column. [1] The United States Pharmacopeia (USP) also describes an HPLC method for the separation and determination of related compound B (meta-fexofenadine) using an expensive β-cyclodextrin-modified silica column (USP L45). [1]
In the stability-indicating HPLC method developed in this literature, meta-fexofenadine (impurity B) was successfully separated from fexofenadine (FEX) and other impurities (A, C, D). Under optimized chromatographic conditions (Hypersil BDS C-18 column; mobile phase: phosphate buffer containing ion-pairing reagent and triethylamine (pH 2.7): methanol (60:40, v/v); flow rate: 1.5 mL/min; detection wavelength: 215 nm), the retention time was 11.987 min. [1] The relative response factor (RRF) of impurity B (meta-fexofenadine) relative to fexofenadine was 0.91. [1] |
| Molecular Formula |
C32H39NO4
|
|---|---|
| Molecular Weight |
501.65636
|
| Exact Mass |
501.288
|
| CAS # |
479035-75-1
|
| Related CAS # |
Meta-Fexofenadine-d6
|
| PubChem CID |
70925805
|
| Appearance |
Off-white to light yellow solid
|
| LogP |
5.448
|
| Hydrogen Bond Donor Count |
3
|
| Hydrogen Bond Acceptor Count |
5
|
| Rotatable Bond Count |
10
|
| Heavy Atom Count |
37
|
| Complexity |
686
|
| Defined Atom Stereocenter Count |
0
|
| SMILES |
CC(C)(c1cccc(c1)C(CCCN2CCC(CC2)C(c3ccccc3)(c4ccccc4)O)O)C(=O)O
|
| InChi Key |
RYHUKJMCYGRCSM-UHFFFAOYSA-N
|
| InChi Code |
InChI=1S/C32H39NO4/c1-31(2,30(35)36)28-16-9-11-24(23-28)29(34)17-10-20-33-21-18-27(19-22-33)32(37,25-12-5-3-6-13-25)26-14-7-4-8-15-26/h3-9,11-16,23,27,29,34,37H,10,17-22H2,1-2H3,(H,35,36)
|
| Chemical Name |
2-[3-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
DMSO: ~50 mg/mL (~99.7 mM; with ultrasonication)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 2.5 mg/mL (4.98 mM) in 10% DMSO + 40% PEG300 + 5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), Suspended solution; with ultrasonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 400 μL of PEG300 and mix well; then add 50 μL of Tween-80 and mix well; finally add 450 μL of physiological saline and adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.98 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), Clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of DMSO stock solution (25.0 mg/mL) to 900 μL of 20% SBE-β-CD saline and mix well. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9934 mL | 9.9669 mL | 19.9338 mL | |
| 5 mM | 0.3987 mL | 1.9934 mL | 3.9868 mL | |
| 10 mM | 0.1993 mL | 0.9967 mL | 1.9934 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Products are for research use only; We do not sell to patients
Copyright 2020 InvivoChem LLC | All Rights Reserved
