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    Megestrol Acetate (BDH1298)
    Megestrol Acetate (BDH1298)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1769
    CAS #: 595-33-5Purity ≥98%

    Description: Megestrol acetate (formerly BDH1298, SC10363; BDH-1298; SC-10363; Megace; Ovaban; Pallace; Maygace; Megestil; Niagestin) is a synthetic progestogen derivative that has been approved for use in the treatment of breast cancer and loss of appetite. Megestrol Acetate shows potent anti-proliferative activity in vitro against various cancer cell lines such as  HepG2 cells with an IC50 value of 260μM.  

    References: Eur J Pharmacol. 2011 Mar 11;654(3):217-25; Aquat Toxicol. 2014 May;150:66-72. 

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    • 香港大学
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    Molecular Weight (MW)384.51
    FormulaC24H32O4 
    CAS No.595-33-5
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 33 mg/mL (85.8 mM)
    Water: <1 mg/mL
    Ethanol: 15 mg/mL (39.0 mM)
    Other info

    Chemical Name: (8R,9S,10R,13S,14S,17R)-17-acetyl-6,10,13-trimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate

    InChi Key: RQZAXGRLVPAYTJ-GQFGMJRRSA-N

    InChi Code: InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3/t18-,19+,20+,22-,23+,24+/m1/s1

    SMILES Code: CC(O[[email protected]]1(C(C)=O)CC[[email protected]@]2([H])[[email protected]]3([H])C=C(C)C4=CC(CC[[email protected]]4(C)[[email protected]@]3([H])CC[[email protected]]12C)=O)=O

    Synonyms

    BDH 1298; SC10363; BDH1298; SC 10363; BDH-1298; SC-10363; Megace; Ovaban; Pallace. Maygace; Megestil; Niagestin.


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    In Vitro

    In vitro activity: Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPβ in reperfusion injury-induced ischemic rat hippocampus. Megestrol acetate significantly increases the proliferation, migration, and adipogenic differentiation of adipose-derived stem cells (ASCs) in a dose-dependent manner. Megestrol acetate also upregulates genes downstream of glucocorticoid receptor (GR) in ASCs.

    In VivoMegestrol acetate significantly decreases the circulating concentrations of estradiol (E2) and testosterone (T) in female fish or 11-ketotestosterone (11-KT) in male fish. Megestrol acetate exposure significantly downregulates the transcription of certain genes along the hypothalamic-pituitary-gonadal (HPG) axis. Megestrol acetate produces a progressive deterioration in glucose tolerance, with a significant increase in mean fasting plasma glucose concentrations and decrease in mean plasma glucose clearance rates after 6 months and 12 months of treatment in cats. Megestrol acetate also produces a progressive decrease in both resting plasma cortisol concentrations and cortisol concentrations after ACTH stimulation in cats. Megestrol acetate (50 mg/kg/day) for 9 days significantly increases food and water intake compared with untreated controls. Megestrol acetate (50 mg/kg/day) significantly (90-140%) increases in neuropeptide Y concentrations in the arcuate nucleus (where neuropeptide Y is synthesized), in the lateral hypothalamic area (through which arcuate neurones project) and in the medial preoptic area, ventromedial nucleus and dorsomedial nucleus in rats.
    Animal modelRats
    Formulation & Dosage50 mg/kg
    References

    Eur J Pharmacol. 2011 Mar 11;654(3):217-25; Aquat Toxicol. 2014 May;150:66-72. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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