Absorption, Distribution and Excretion
Intestinal absorption primarily occurs via passive diffusion. Excretion is mainly via the kidneys; during hypermagnesemia, up to 97% of magnesium is excreted through the kidneys. The volume of distribution for magnesium ions is approximately 0.2 to 0.4 L/kg/hr. Biological Half-Life It has been reported that the elimination half-life after an overdose of 400 mEq magnesium in adults is 27.7 hours.

Protein Binding
The protein binding rate of magnesium ions is approximately 30%.

[1]. Thermal dehydration of magnesium acetate tetrahydrate: formation and in situ crystallization of anhydrous glass. J Phys Chem B. 2012 Dec 13;116(49):14477-86.

Magnesium acetate tetrahydrate is the hydrated form of anhydrous magnesium acetate, with the chemical formula Mg(CH3COO)2·4H2O. As a magnesium salt, magnesium acetate is one of the most bioavailable forms of magnesium and is highly soluble in water. Magnesium is an essential element for the human body and the second most abundant cation in the body, playing a crucial role in maintaining normal cellular functions, such as ATP production and efficient enzyme activity. Magnesium acetate tetrahydrate can be used as an electrolyte supplement or as a reagent in molecular biology experiments. Magnesium acetate tetrahydrate is the hydrated acetate form of magnesium. Magnesium is a divalent cation, essential for many biochemical processes, including nerve signal transduction, bone mineralization, and muscle contraction. Approximately 350 enzymes involved in glycolysis and the Krebs cycle, cyclic adenosine monophosphate (cAMP) and adenosine triphosphate (ATP) production, cell signal transduction, and protein and nucleic acid synthesis depend on magnesium. See also: Magnesium ions (with active moiety)... See more...

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Drug Indications
Used as a magnesium salt laxative to prevent constipation. When used in combination with aluminum salts that can cause intestinal retention, it can produce a synergistic effect, restoring normal intestinal function. Magnesium acetate tetrahydrate, when mixed with glucose and other salts to form an intravenous infusion, can serve as a source of water and electrolytes. This injection can be used for patients with carbohydrate or magnesium deficiency, insulin hypoglycemia, constipation, or gestational hypertension.

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Mechanism of Action
Magnesium ions stabilize the adenylate cyclase complex through electrostatic interactions, enhancing its catalytic activity and cAMP production. They also regulate phosphorylation levels in various pathways by forming transition states of phosphotransferase reactions through protein kinases and stabilize the binding of ATP to protein kinases through electrostatic interactions. Many metabolic enzymes involved in glycolysis and the tricarboxylic acid cycle depend on magnesium. Magnesium-containing laxatives stimulate intestinal peristalsis by retaining water and increasing stool volume, thereby causing diarrhea. When used as an electrolyte supplement, magnesium acetate tetrahydrate can induce diuresis and produce metabolic alkalization. Magnesium ions enhance the responsiveness of arteries to vasoconstrictors, promote vasoconstriction, and increase peripheral resistance, potentially leading to increased blood pressure by competing with calcium ions in the vascular system. Magnesium ions also regulate the movement of other ions across cell membranes by acting as ligands for the N-methyl-D-aspartate receptor.

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Pharmacodynamics
Magnesium is an essential cofactor for many enzymatic reactions, such as protein synthesis and ATP production. It is also involved in the adenylate cyclase pathway and the tyrosine kinase signaling pathway. Magnesium may also play a role in regulating glucose metabolism. It is an essential cation for many biochemical processes, including nerve signaling, bone mineralization, and muscle contraction.

C4H14MGO8

214.4542

214.054

16674-78-5

Acetic acid potassium 99%;127-08-2;Acetic acid;64-19-7;Acetic acid lead;546-67-8

134717

Typically exists as solid at room temperature

1.454

117.1ºC at 760 mmHg

72-75 °C(lit.)

13.9mmHg at 25°C

n20/D 1.358

4

8

0

13

25.5

0

[Mg+2].[O-]C(C([H])([H])[H])=O.[O-]C(C([H])([H])[H])=O.O([H])[H].O([H])[H].O([H])[H].O([H])[H]

XKPKPGCRSHFTKM-UHFFFAOYSA-L

InChI=1S/2C2H4O2.Mg.4H2O/c2*1-2(3)4;;;;;/h2*1H3,(H,3,4);;4*1H2/q;;+2;;;;/p-2

magnesium;diacetate;tetrahydrate

2934.99.9001

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

DMSO : ~100 mg/mL (~466.31 mM)

Solubility in Formulation 1: ≥ 2.5 mg/mL (11.66 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL.
Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.

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Solubility in Formulation 2: ≥ 2.5 mg/mL (11.66 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.

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Solubility in Formulation 3: ≥ 2.5 mg/mL (11.66 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.

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 (Please use freshly prepared in vivo formulations for optimal results.)