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      Luteolin
      Luteolin

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      This product is for research use only, not for human use. We do not sell to patients.
      Number： - + Pieces（InventoryPieces）
      InvivoChem Cat #: V0799
      CAS #: 491-70-3Purity ≥98%

      Description: Luteolin (also known as Digitoflavone; Salifazide; BRN0292084; RN 0292084; Luteolol) is a naturally occuring flavonoid isolated from plants such as Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki values of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Luteolin has antioxidant and pro-oxidant activity, and plants rich in luteolin have been used in Chinese traditional medicine.

      References: Eur J Pharmacol. 2010 Feb 10;627(1-3):269-75; J Pharmacol Exp Ther. 2001 Jan;296(1):181-7.

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      Molecular Weight (MW)286.24
      FormulaC15H10O6
      CAS No.491-70-3
      Storage-20℃ for 3 years in powder form
      -80℃ for 2 years in solvent
      Solubility (In vitro)DMSO: 57 mg/mL (199.1 mM)
      Water:<1 mg/mL
      Ethanol: 3 mg/mL (10.5 mM)
      Other info

      Chemical Name: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4-benzopyrone

      InChi Key: IQPNAANSBPBGFQ-UHFFFAOYSA-N

      InChi Code: InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H

      SMILES Code: O=C1C=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13

      SynonymsFlacitran; Luteoline; Luteolol; BRN-0292084; BCyanidenon 1470; Digitoflavone; Salifazide; Luteolin; BRN0292084; RN 0292084; C.I. 75590; C.I. Natural Yellow 2; CCRIS 3790; 


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      In Vitro

      In vitro activity: Luteolin is a flavonoid found in Terminalia chebula, which is a non-selective phisphodiesterase PDE inhibitor for PDE1-5 with Ki of 15.0 μM, 6.4 μM, 13.9 μM, 11.1 μM and 9.5 μM, respectively. Luteolin inhibits LPS-stimulated TNF-alpha production with an IC50 of less than 1 μM. Luteolin inhibites LPS-induced phosphorylation of Akt as well as IkappaBalpha.

      Cell Assay: Luteolin (0-160 µM; 24 hours; NCI-H460 cells) treatment inhibits the viability of NCI-H460 cells in a concentration-dependent manner. Luteolin (20-80 µM; 24 hours; NCI-H460 cells) treatment causes an accumulation of cells in the S phase. Luteolin (320-580 µM; 48 hours; NCI-H460 cells) treatment induces apoptosis.
      Luteolin (20-80 µM; 24 hours; NCI-H460 cells) treatment increases the protein expression levels of apoptotic regulatory proteins, including the Bax/Bcl-2 ratio, in a concentration-dependent manner, however, only 80 µM Luteolin inhibits the expression of Bad. Luteolin also decreases the expression of Sirt1 in the NCI-H460 cell line in a concentration-dependent manner

      In VivoLuteolin (10-100 mg/kg; oral gavage; daily; for 12 weeks; adult male Wistar rats) has an antioxidant effect and can also protect against non-alcoholic steatohepatitis through targeting the pro-inflammatory IL-1 and Il-18 pathways in rats with a high carbohydrate/high fat diet
      Animal modelMale Wistar rats
      Formulation & Dosage10-100 mg/kg; oral gavage
      References

      Eur J Pharmacol. 2010 Feb 10;627(1-3):269-75; J Pharmacol Exp Ther. 2001 Jan;296(1):181-7.

      These protocols are for reference only. InvivoChem does not independently validate these methods.

      Luteolin

      Quercetin and luteolin inhibit nitrite accumulation. J Pharmacol Exp Ther. 2001 Jan;296(1):181-7.
      		 

      Luteolin

      Luteolin inhibits LPS-induced IκB-α degradation and NF-κB-mediated promoter activity. J Pharmacol Exp Ther. 2001 Jan;296(1):181-7.
      		 

      Luteolin

      Luteolin inhibits LPS-induced Akt phosphorylation. J Pharmacol Exp Ther.2001 Jan;296(1):181-7.

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