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    Loxistatin Acid (E-64C; NSC694279; EP475)
    Loxistatin Acid (E-64C; NSC694279; EP475)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0700
    CAS #: 76684-89-4Purity ≥98%

    Description: Loxistatin Acid (formerly also known as E-64C; NSC-694279; EP-475), an analog of E-64, is a novel, potent, irreversible and membrane-permeable cysteine protease inhibitor with important biological activity. E-64-c has proved to be substantially more reactive than E-64 with cathepsins B and L. Cathepsins B and H from human liver and rat cathepsin L were used to measure the rate constants of inhibition of E-64-c, which indicated the rate constants of inactivation of cathepsins B, H and L were 298000, 2018, 206000 M-1 s-1 , respectively.

    References: Biochem Biophys Res Commun. 1989 Jan 31;158(2):432-5; J Neurosci Res. 2003 Nov 1;74(3):393-405.

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    Molecular Weight (MW)314.38
    CAS No.76684-89-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 62 mg/mL (197.2 mM)
    Water: 2 mg/mL (6.4 mM)
    Ethanol: 62 mg/mL (197.2 mM)
    Solubility (In vivo)Saline: 2mg/mL  
    SynonymsNSC-694279; EP-475; E64-C; NSC 694279; EP 475; E64 C; NSC694279; EP475; E64C; Loxistatin Acid; 

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    In Vitro

    In vitro activity: Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease.

    In VivoIn pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. 
    Animal modelMale Sprague-Dawley rats.
    Formulation & DosageDissolved in a small amount of saturated bicarbonate solution and then diluted with 0.9% NaCl saline; 400 mg/kg; i.p. injection  

    Biochem Biophys Res Commun. 1989 Jan 31;158(2):432-5; J Neurosci Res. 2003 Nov 1;74(3):393-405; J Biol Chem. 1991 Aug 5;266(22):14771-7.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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