Size | Price | Stock | Qty |
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250mg |
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500mg |
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1g |
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2g |
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5g |
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10g |
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25g |
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Other Sizes |
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Purity: ≥98%
Lisinopril hydrate (MK-521), an enalapril analog, is a potent angiotensin-converting enzyme (ACE) inhibitor used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes. Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain.
ln Vitro |
The enzyme that changes angiotensin I (ATI) into angiotensin II (ATII) is called angiotensin-converting enzyme (ACE), and lisinopri dihydrate is a strong and competitive inhibitor of this enzyme. Renin-angiotensin-aldosterone system (RAAS) constituent ATII controls blood pressure. Lisinopril is prescribed to treat hypertension, symptomatic congestive heart failure, to prolong survival following myocardial infarction in some patients, and to stop the advancement of renal disease in hypertensive patients with diabetes, microalbuminuria, or overt nephropathy [1][2].
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References |
[1]. Andujar-Sanchez, M., V. Jara-Perez, and A. Camara-Artigas, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett, 2007. 581(18): p. 3449-54.
[2]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24. |
Molecular Formula |
C21H35N3O7
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Molecular Weight |
441.52
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CAS # |
83915-83-7
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Related CAS # |
Lisinopril;76547-98-3;Lisinopril-d5;1356905-39-9
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SMILES |
O=C(O)[C@H]1N(C([C@H](CCCCN)N[C@H](C(O)=O)CCC2=CC=CC=C2)=O)CCC1.[H]O[H].[H]O[H]
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InChi Key |
CZRQXSDBMCMPNJ-ZUIPZQNBSA-N
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InChi Code |
InChI=1S/C21H31N3O5.2H2O/c22-13-5-4-9-16(19(25)24-14-6-10-18(24)21(28)29)23-17(20(26)27)12-11-15-7-2-1-3-8-15/h1-3,7-8,16-18,23H,4-6,9-14,22H2,(H,26,27)(H,28,29)2*1H2/t16-,17-,18-/m0../s1
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Chemical Name |
((S)-1-carboxy-3-phenylpropyl)-L-lysyl-L-proline dihydrate
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Synonyms |
MK-521 MK521 MK 521Lisinopril dihydrate Prinivil Qbrelis Ranolip Renacor
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
H2O : ~33.33 mg/mL (~75.49 mM)
DMSO : ~1 mg/mL (~2.26 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: 50 mg/mL (113.25 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
 (Please use freshly prepared in vivo formulations for optimal results.) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.2649 mL | 11.3245 mL | 22.6490 mL | |
5 mM | 0.4530 mL | 2.2649 mL | 4.5298 mL | |
10 mM | 0.2265 mL | 1.1325 mL | 2.2649 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.