| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg | |||
| Other Sizes |
Purity: ≥98%
| Targets |
Licochalcone C targets multiple enzymes and pathways. It is a potent inhibitor of α-glucosidase, an enzyme involved in carbohydrate digestion. It also exhibits inhibitory activity against phosphatases. Its anti-inflammatory effects are attributed to its inhibition of lipopolysaccharide-interferon-γ-induced inflammation. Its antioxidant properties contribute to its biological activities.
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| ln Vitro |
Licochalcone C has the ability to inhibit α-glucosidase, with IC50 values for PTP1B and α-glucosidase of 92.43 μM and less than 100 nM, respectively [1]. It was also demonstrated that licochalcone C induced apoptosis in T24 cells in a concentration-dependent manner. After being treated with licorice cone C, pro-apoptotic mRNAs (Bax and Bim) were more highly expressed whereas anti-apoptotic mRNAs (Bcl-2, Bcl-w, and Bcl-XL) were less abundant. ABT-737, a Bcl-2 family inhibitor, can lessen the amount of apoptosis that licoricechalcone C induces in T24 cells [2].
Licochalcone C demonstrates potent in vitro activity as an α-glucosidase inhibitor. It has potent antioxidant properties and inhibits bacterial growth and cellular respiration. It is a potent inhibitor of lipopolysaccharide-interferon-γ inflammation. Its activity has been confirmed in various biochemical and cellular assays. |
| ln Vivo |
Licochalcone C is a naturally occurring compound with potential therapeutic applications in diabetes, metabolic disease, and inflammation. Its ability to inhibit α-glucosidase suggests it could be useful for managing postprandial blood glucose levels. Its anti-inflammatory and antioxidant properties may contribute to its beneficial effects in various disease models.
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| Enzyme Assay |
The primary in vitro assays for Licochalcone C include α-glucosidase inhibition assays, where the enzyme is incubated with a substrate and the compound, and the production of the product is measured spectrophotometrically. Antioxidant activity is assessed using standard free radical scavenging assays. Anti-inflammatory activity can be assessed by measuring the inhibition of inflammatory mediators in cell-based assays.
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| Cell Assay |
In vitro cellular experiments involve treating immune cells or other cell types with Licochalcone C and measuring its effects on inflammatory responses, oxidative stress, and cell viability. The compound's ability to inhibit LPS-induced inflammation can be assessed by measuring the production of pro-inflammatory cytokines. Its effects on bacterial growth can be assessed in culture.
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| Animal Protocol |
In vivo animal experiments for Licochalcone C would involve administering the compound to animal models of diabetes, inflammation, or metabolic disease to assess its therapeutic efficacy. Its effects on blood glucose levels, inflammatory markers, and disease progression would be evaluated. However, specific in vivo data is not detailed in the provided sources.
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| ADME/Pharmacokinetics |
Licochalcone C has a molecular weight of 338.40 g/mol and a molecular formula of C21H22O4. It is a naturally occurring chalcone with a purity of ≥95%. The compound is typically used as a research reagent in metabolomics, vitamins, nutraceuticals, and natural product research.
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| Toxicity/Toxicokinetics |
Toxicological data for Licochalcone C is not detailed in the provided sources. As a naturally occurring compound, it is generally considered to have low toxicity. However, as a research compound, it is not intended for human use. Standard safety precautions should be followed when handling.
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| References |
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| Additional Infomation |
It has been reported that licorice (Glycyrrhiza glabra) and inflated licorice (Glycyrrhiza inflata) contain glycyrrhizin C, and relevant data are available for reference.
Licochalcone C is a naturally occurring chalcone from Glycyrrhiza glabra with potent antioxidant, anti-inflammatory, and α-glucosidase inhibitory activities. It is a potent inhibitor of lipopolysaccharide-interferon-γ inflammation. The compound is of interest for research in diabetes, metabolic disease, and inflammation. It is available from various chemical suppliers for research purposes. |
| Molecular Formula |
C21H22O4
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|---|---|
| Molecular Weight |
338.3970
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| Exact Mass |
338.151
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| CAS # |
144506-14-9
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| Related CAS # |
144506-14-9
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| PubChem CID |
9840805
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.2±0.1 g/cm3
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| Boiling Point |
536.1±50.0 °C at 760 mmHg
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| Flash Point |
188.4±23.6 °C
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| Vapour Pressure |
0.0±1.5 mmHg at 25°C
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| Index of Refraction |
1.622
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| LogP |
4.9
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
4
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| Rotatable Bond Count |
6
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| Heavy Atom Count |
25
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| Complexity |
484
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| Defined Atom Stereocenter Count |
0
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| SMILES |
O(C([H])([H])[H])C1=C(/C(/[H])=C(\[H])/C(C2C([H])=C([H])C(=C([H])C=2[H])O[H])=O)C([H])=C([H])C(=C1C([H])([H])/C(/[H])=C(\C([H])([H])[H])/C([H])([H])[H])O[H]
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| InChi Key |
WBDNTJSRHDSPSR-KPKJPENVSA-N
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| InChi Code |
InChI=1S/C21H22O4/c1-14(2)4-11-18-20(24)13-8-16(21(18)25-3)7-12-19(23)15-5-9-17(22)10-6-15/h4-10,12-13,22,24H,11H2,1-3H3/b12-7+
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| Chemical Name |
(E)-3-[4-Hydroxy-2-methoxy-3-(3-methylbut-2-enyl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one InChi Key
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| Synonyms |
LicoC Lico-C Lico CLicochalcone-C
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~33.33 mg/mL (~98.49 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (7.39 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.39 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.9551 mL | 14.7754 mL | 29.5508 mL | |
| 5 mM | 0.5910 mL | 2.9551 mL | 5.9102 mL | |
| 10 mM | 0.2955 mL | 1.4775 mL | 2.9551 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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