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    Levetiracetam (UCB-L 059, SIB-S 1)
    Levetiracetam (UCB-L 059, SIB-S 1)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0335
    CAS #: 102767-28-2Purity ≥98%

    Description: Levetiracetam (also known as UCB-L059, SIB-S1) is a potent and selective M2 muscarinic acetylcholine receptors (mAChR) inhibitor and an anticonvulsant medication used to treat epilepsy. Levetiracetam and related compounds bind to SV2A expressed in fibroblasts, indicating that SV2A is sufficient for Levetiracetam binding. Levetiracetam irreversibly inhibits the high-voltage-activated (HVA) calcium current by approximately 18% on the average in freshly isolated CA1 hippocampal neurons of rats. Levetiracetam selectively inhibits N-type Ca2+ channels of CA1 pyramidal hippocampal neurons.

    References: Nature. 2005 May 26;435(7041):519-22; Br J Pharmacol. 2002 Jul;136(5):659-72.

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    Molecular Weight (MW)170.21 
    FormulaC8H14N2O2 
    CAS No.102767-28-2 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 34 mg/mL (199.8 mM)
    Water: 34 mg/mL (199.8 mM)
    Ethanol: 34 mg/mL (199.8 mM)  
    Solubility (In vivo)Saline: 30 mg/mL 
    Synonyms Levetiracetam, UCBL059, UCB L059, UCB-L059, SIB S1, SIBS1, SIB-S1, Keppra, Etiracetam, UCB6474, UCB-6474,

     UCB 6474,

    Chemical Name: (S)-2-(2-oxopyrrolidin-1-yl)butanamide

    InChi Key: HPHUVLMMVZITSG-LURJTMIESA-N

    InChi Code: InChI=1S/C8H14N2O2/c1-2-6(8(9)12)10-5-3-4-7(10)11/h6H,2-5H2,1H3,(H2,9,12)/t6-/m0/s1

    SMILES Code: O=C(N)[[email protected]](CC)N1C(CCC1)=O


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    In Vitro

    In vitro activity: Levetiracetam and related compounds bind to SV2A expressed in fibroblasts, indicating that SV2A is sufficient for Levetiracetam binding. Levetiracetam irreversibly inhibits the high-voltage-activated (HVA) calcium current by approximately 18% on the average in freshly isolated CA1 hippocampal neurons of rats. Levetiracetam selectively inhibits N-type Ca2+ channels of CA1 pyramidal hippocampal neurons. Levetiracetam reverses the inhibitory effect of DMCM on GABA-elicited currents in hippocampal neurons

    In VivoLevetiracetam (17 mg/kg) produces a potent suppression of sound-induced clonic convulsions in mice, and this protective effect is significantly abolished by co-administration of the beta-carboline FG 7142. Levetiracetam exerts potent anticonvulsant activity against both focal and secondarily generalized seizures in fully amygdala-kindled rats, i.e. , a model of temporal lobe epilepsy. Levetiracetam (13 mg/kg, 27 mg/kg or 54 mg/kg, i.p.) dose-dependently suppresses the increase in seizure severity and duration induced by repeated amygdala stimulation. Levetiracetam has a relatively short half-life (about 2-3 hours) in rats. Levetiracetam (5.4 mg/kg to 96 mg/kg i.p.) dose-dependently inhibits both wild running and tonic-clonic convulsions in the audiogenic-seizure prone rat. Levetiracetam markedly suppresses spontaneous spike-and-wave discharge (SWD) but leaves the underlying EEG trace normal in the GAERS model of petit mal epilepsy. 
    Animal modelMice
    Formulation & Dosage5.4 mg/kg to 96 mg/kg i.p
    References

    Nature. 2005 May 26;435(7041):519-22; Br J Pharmacol. 2002 Jul;136(5):659-72. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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