Size | Price | Stock | Qty |
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500mg |
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1g |
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2g |
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5g |
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10g |
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Other Sizes |
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Purity: ≥98%
Lansoprazole (formerly A65006, AG1749; A-65006, AG-1749; trade name Prevacid, Zoton, Agopton, Bamalite, Opiren), a prescription and OTC drug for treatment for heartburn, is a potent and next generation proton-pump inhibitor (PPI) which prevents the stomach from producing gastric acid. Lansoprazole has the same pharmacologic class as omeprazole which inhibits the stomach's production of gastric acids. Research is underway for analogs of lansoprazole to explore their use as potential PET imaging agents for diagnosing tauopathies including Alzheimer's disease. Lansoprazole is also a prodrug that targets the cytochrome bc1 complex of Mycobacterium tuberculosis once converted to lansoprazole sulfide in mycobacterial host cells.
ln Vitro |
In a concentration-dependent manner (IC50 of 0.76 μM), lansoprazole at 0.3 to 3 μM suppresses the production of stomach acid [4]. Arterial relaxation that is concentration-dependent, reversible, and repeatable is induced by lansoprazole (30–300 μM) [5].
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ln Vivo |
Treatment with lansoprazole (20–40 mg/kg) significantly improves memory impairments as well as biochemical and histological alterations brought on by STZ and HFD [3]. The oral doses of lansoprazole (20 mg/kg and 40 mg/kg) considerably lessen the elevations in AChE activity that are caused by STZ and HFD [3]. The oral doses of lansoprazole (20 mg/kg and 40 mg/kg) considerably decrease the elevations in brain MPO levels caused by STZ and HFD [3]. When compared to control animals, other HFD mice given oral doses of Lansoprazole (20 mg/kg and 40 mg/kg) lost a considerable amount of weight [3].
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Animal Protocol |
Animal/Disease Models: Swiss albino mice (20–25 g) of either sex[3].
Doses: 20 mg/kg, 40 mg/kg. Route of Administration: PO, started after second dose of STZ and then subjected to MWM test. Continued ( 30 min before) during the acquisition trial conducted from day 1 to day 4. Experimental Results: Dramatically attenuated the day 4 rise in ELT and diminished in day 5 TSTQ in the STZ as well as HFD treated mice in a dose dependent manner. |
References |
[1]. Kokufu, T., et al., Effects of lansoprazole on pharmacokinetics and metabolism of theophylline. Eur J Clin Pharmacol, 1995. 48(5): p. 391-5.
[2]. Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330. [3]. Rupinder K Sodhi, et al. Defensive effect of lansoprazole in dementia of AD type in mice exposed to streptozotocin and cholesterol enriched diet. PLoS One. 2013 Jul 31;8(7):e70487. [4]. Jun Matsukawa, et al. A comparative study on the modes of action of TAK-438, a novel potassium-competitive acid blocker, and lansoprazole in primary cultured rabbit gastric glands. Biochem Pharmacol. 2011 May 1;81(9):1145-51. [5]. Erdinc Naseri, et al. Proton pump inhibitors omeprazole and lansoprazole induce relaxation of isolated human arteries. Eur J Pharmacol. 2006 Feb 15;531(1-3):226-31. |
Molecular Formula |
C16H14F3N3O2S
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Molecular Weight |
369.36
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CAS # |
103577-45-3
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SMILES |
S(C1=NC2=C([H])C([H])=C([H])C([H])=C2N1[H])(C([H])([H])C1C(C([H])([H])[H])=C(C([H])=C([H])N=1)OC([H])([H])C(F)(F)F)=O
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Synonyms |
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
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Solubility (In Vivo) |
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 2.7074 mL | 13.5369 mL | 27.0739 mL | |
5 mM | 0.5415 mL | 2.7074 mL | 5.4148 mL | |
10 mM | 0.2707 mL | 1.3537 mL | 2.7074 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.