| Size | Price | Stock | Qty |
|---|---|---|---|
| 250mg |
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| 500mg |
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| 1g |
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| Other Sizes |
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| ln Vitro |
Prostate cancer cells are selectively inhibited from growing when exposed to L-selenomethylthionine (1-500 μM; 24-72 h) in comparison to normal cells [2]. Prostate cancer cells undergo apoptosis when exposed to 500 μM of selenium [2]. Prostate cancer cells are selectively subjected to increased G2-M cell cycle arrest when exposed to 500 μM of seleniumethionine for 48 hours [2]. Gene expression linked to the cellular stress response to 10 cGy radiation is suppressed by L-selenomethionine (5 μM; 24 hours) [4].
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|---|---|
| ln Vivo |
In rats exposed to gamma rays, protons, or HZE particles, L-selenomethionine (0.06–12 μg/g diet; orally for 3 days) either partially or totally reversed the decline in serum or plasma total antioxidant levels [5].
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| Cell Assay |
Cell viability assay[2]
Cell Types: prostate cancer cells (LNCaP, PC-3 and DU145) and normal prostate cells (PrEC, PrSM and PrSt) Tested Concentrations: 1, 5, 10, 50, 100, 500 μM Incubation Duration: 24 , 48 and 72 hour Experimental Results: Inhibited the growth of prostate cancer cells, the IC50 (1-90 μM) at 72 hrs (hours) was lower than that of normal prostate cells (>500 μM). Apoptosis analysis[2] Cell Types: Prostate cancer cells (LNCaP, PC-3 and DU145) and normal prostate cells (PrEC, PrSM and PrSt) Tested Concentrations: 500 μM Incubation Duration: 48 hrs (hours) Experimental Results: demonstrated the highest levels of DNA Coagulation occurred in androgen-responsive LNCaP cancer cells, followed by PC-3 and DU145 cells. Nick end DNA labeling in prostate cancer cells is demonstrated. Promotes PARP cleavage in prostate cancer cells. Cell cycle analysis[2] Cell Types: Prostate cancer cells (LNCaP, PC-3 and DU145) and normal prostate cells (PrEC, PrSM and PrSt) Tested Concentrations: 500 μM Incubation Duration: 48 hrs (hours) Experimental Results: Sub-G0 increase -LNCaP (41.5 %) |
| References |
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| Additional Infomation |
L-selenomethionine is the L-enantiomer of selenomethionine. It is an enantiomer of a D-selenomethionine. It is a tautomer of a L-selenomethionine zwitterion.
L-selenomethionine has been reported in Brassica oleracea, Allium sativum, and other organisms with data available. L-Selenomethionine is the amino acid methionine with selenium substituting for the sulphur moiety. Methionine is an essential amino acid in humans, whereas selenium is a free-radical scavenging anti-oxidant, essential for the protection of various tissues from the damages of lipid peroxidation. As a trace mineral that is toxic in high doses, selenium is a cofactor for glutathione peroxidase, an anti-oxidant enzyme that neutralizes hydrogen peroxide. L-Selenomethionine is considered a safe, efficacious form of selenium and is readily bioavailable. Selenium may be chemoprotective for certain cancers, particularly prostate cancer. (NCI04) Diagnostic aid in pancreas function determination. |
| Molecular Formula |
C5H11NO2SE
|
|---|---|
| Molecular Weight |
196.10634
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| Exact Mass |
196.995
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| CAS # |
3211-76-5
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| Related CAS # |
Selenomethionine;1464-42-2
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| PubChem CID |
105024
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| Appearance |
White to off-white solid powder
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| Boiling Point |
320.8±37.0 °C at 760 mmHg
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| Melting Point |
265 °C
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| Flash Point |
147.8±26.5 °C
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| Vapour Pressure |
0.0±1.5 mmHg at 25°C
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| Index of Refraction |
18 ° (C=0.5, 2mol/L HCl)
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| LogP |
-0.65
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| Hydrogen Bond Donor Count |
2
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| Hydrogen Bond Acceptor Count |
3
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
9
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| Complexity |
97
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| Defined Atom Stereocenter Count |
1
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| SMILES |
C[Se]CC[C@@H](C(=O)O)N
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| InChi Key |
RJFAYQIBOAGBLC-BYPYZUCNSA-N
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| InChi Code |
InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
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| Chemical Name |
(2S)-2-amino-4-methylselanylbutanoic acid
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~14.29 mg/mL (~72.87 mM)
DMSO : ~1 mg/mL (~5.10 mM) |
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 9.09 mg/mL (46.35 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C).
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 5.0992 mL | 25.4959 mL | 50.9918 mL | |
| 5 mM | 1.0198 mL | 5.0992 mL | 10.1984 mL | |
| 10 mM | 0.5099 mL | 2.5496 mL | 5.0992 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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