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    JNJ-61432059
    JNJ-61432059

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4514
    CAS #: 2035814-50-5Purity ≥98%

    Description: JNJ-61432059 is a novel, potent, oral bioactive and selective negative modulator of AMPAR (α-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors) associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC50 of 9.7 for GluA1/γ-8. It exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models.  

    References:  2018 Dec 26;10(3):267-272. 


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    JNJ-61432059

    Name: JNJ-61432059
    CAS#: 2035814-50-5
    Chemical Formula: C25H22FN5O2
    Exact Mass: 443.1758
    Molecular Weight: 443.4824
    Elemental Analysis: C, 67.71; H, 5.00; F, 4.28; N, 15.79; O, 7.22
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: JNJ-61432059; JNJ 61432059; JNJ61432059;
    IUPAC/Chemical Name: 5-[2-(4-fluorophenyl)-7-(4-hydroxy-1-piperidyl)pyrazolo[1,5-c]pyrimidin-3-yl]indolin-2-one.
    InChi Key: UWIJVELUZWBFEU-UHFFFAOYSA-N
    InChi Code: InChI=1S/C25H22FN5O2/c26-18-4-1-15(2-5-18)24-23(16-3-6-20-17(13-16)14-22(33)28-20)21-7-10-27-25(31(21)29-24)30-11-8-19(32)9-12-30/h1-7,10,13,19,32H,8-9,11-12,14H2,(H,28,33)
    SMILES Code: O=C1NC2=C(C=C(C3=C4N(N=C3C5=CC=C(F)C=C5)C(N6CCC(O)CC6)=NC=C4)C=C2)C1


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