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    JNJ-42165279
     JNJ-42165279

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4504
    CAS #: 1346528-50-4Purity ≥98%

    Description: JNJ-42165279 is a novel, potent, covalent and selective FAAH (fatty acid amide hydrolase) inhibitor with IC50 of 70 ± 8 nM and 313 ± 28 nM for hFAAH and rFAAH, respectively. JNJ-42165279 covalently inactivates the FAAH enzyme, but is highly selective with regard to other enzymes, ion channels, transporters, and receptors. JNJ-42165279 exhibited excellent ADME and pharmacodynamic properties as evidenced by its ability to block FAAH in the brain and periphery of rats and thereby cause an elevation of the concentrations of anandamide (AEA), oleoyl ethanolamide (OEA), and palmitoyl ethanolamide (PEA). The compound was also efficacious in the spinal nerve ligation (SNL) model of neuropathic pain. The combination of good physical, ADME, and PD properties of JNJ-42165279 supported it entering the clinical portfolio.

    References:  2015 Nov 2;6(12):1204-8.

    Related CAS : 1346528-50-4 (free base); 1346528-52-6 (HCl salt); 1346528-51-5 (2HCl salt)


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     JNJ-42165279

    Name: JNJ-42165279
    CAS#: 1346528-50-4 (free base); 1346528-52-6 (HCl salt); 1346528-51-5 (2HCl salt)
    Chemical Formula: C18H17ClF2N4O3
    Exact Mass: 410.09572
    Molecular Weight: 410.81
    Elemental Analysis: C, 52.63; H, 4.17; Cl, 8.63; F, 9.25; N, 13.64; O, 11.68
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: JNJ-42165279; JNJ 42165279; JNJ42165279.
    IUPAC/Chemical Name: N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)piperazine-1-carboxamide
    InChi Key: YWGYNGCRVZLMCS-UHFFFAOYSA-N
    InChi Code: InChI=1S/C18H17ClF2N4O3/c19-13-3-4-22-10-14(13)23-17(26)25-7-5-24(6-8-25)11-12-1-2-15-16(9-12)28-18(20,21)27-15/h1-4,9-10H,5-8,11H2,(H,23,26)
    SMILES Code: O=C(N1CCN(CC2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=C(Cl)C=CN=C4


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      JNJ-42165279


    Efficacy of JNJ-42165279 in the rat SNL model of neuropathic pain. ACS Med Chem Lett. 2015 Dec 10; 6(12): 1204–1208.


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