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    Isovaleramide
    Isovaleramide

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V0869
    CAS #: 541-46-8Purity ≥98%

    Description: Isovaleramide (NPS-1776; NPS 1776; NPS1776; 3-Methylbutanamide), a natural product found in Valeriana pavonii, is a potent anticonvulsant agent that acts as an inhibitor of alcohol dehydrogenases. Isovaleramide (300 µM) exhibits a 42% of inhibition of the binding of ³H-FNZ to its sites in the in vitro assay. Isovaleramide showed no effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied.

    References: Biomedica. 2010 Apr-Jun;30(2):245-50; Epilepsy Res. 2004 Sep-Oct;61(1-3):1-48.

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    Molecular Weight (MW)101.15
    FormulaC5H11NO
    CAS No.541-46-8
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 20 mg/mL (197.7 mM)
    Water: <1 mg/mL
    Ethanol: 20 mg/mL (197.7 mM)
    Other info

    Chemical Name: 3-Methylbutanamide

    InChi Key: SANOUVWGPVYVAV-UHFFFAOYSA-N

    InChi Code: InChI=1S/C5H11NO/c1-4(2)3-5(6)7/h4H,3H2,1-2H3,(H2,6,7)

    SMILES Code: CC(C)CC(N)=O

    Synonyms

    3-Methylbutanamide; NPS-1776; Isovaleramide; NPS 1776; NPS1776;


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    In Vitro

    In vitro activity: Isovaleramide is an anticonvulsant molecule isolated from Valeriana pavonii, it inhibits the liver alcohol dehydrogenases. It is isolated from the most active fraction of Valeriana pavonii. Isovaleramide (300 µM) exhibits a 42% of inhibition of the binding of ³H-FNZ to its sites in the in vitro assay. Isovaleramide is without effect at concentrations up to 1000 μM in a variety of in vitro neurotransmitter binding or uptake assays, suggesting that its action does not involve a direct receptor-mediated effect at those systems studied. Isovaleramide (0.15%) induces the formation of nitrile hydratase in Rhodococcus sp. YH 3-3.

    In VivoIsovaleramide (100 mg/Kg, p.o) evidences a 90% index protection against the maximal electroshock seizure in mice (MES). Isovaleramide produces a consistent pattern of signs at relatively high doses in extensive safety studies in rats, rabbits, and dogs. Isovaleramide shows a significantly lower potential for reproductive toxicity than VPA in several reproductive toxicity studies conducted in mice, rats and rabbits. 
    Animal modelMice
    Formulation & Dosage100 mg/Kg, p.o
    References

     Biomedica. 2010 Apr-Jun;30(2):245-50; Epilepsy Res. 2004 Sep-Oct;61(1-3):1-48.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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