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    Ipratropium Bromide (Sch 1000)
    Ipratropium Bromide (Sch 1000)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1178
    CAS #: 22254-24-6 Purity ≥98%

    Description: Ipratropium Bromide (Sch 1000; Sch1000; Atrovent, Apovent, Ipraxa, Rinatec) is a potent antagonist of M3 type muscarinic acetylcholine receptors that opens up the medium and large airways in the lungs. It is used for the treatment of chronic obstructive pulmonary disease (COPD) and asthma. Ipratropium bromide combined with Formoterol partially protects the lungs against the chronic inflammation and airspace enlargement by reducing neutrophilic infiltration possibly via the inhibition of MMP-9 activity. Ipratropium bromide (1 nM) significantly increases [Ca(2+)](i), decreases forward scatter and increases annexin-V-binding. Ipratropium bromide treatment is followed by slight but significant increase of hemolysis.

    References: Eur J Pharmacol. 2010 Nov 25;647(1-3):178-87; Equine Vet J. 1999 Jan;31(1):20-4.

    Related CAS #: 60205-81-4

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    Molecular Weight (MW)412.37 
    FormulaC20H30BrNO3 
    CAS No.22254-24-6 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 83 mg/mL (201.3 mM) 
    Water: 83 mg/mL (201.3 mM) 
    Ethanol: 83 mg/mL (201.3 mM) 
    Other infoChemical Name: [(1S,5R)-8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;bromide
    InChi Key: LHLMOSXCXGLMMN-CLTUNHJMSA-M
    InChi Code: InChI=1S/C20H30NO3.BrH/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H/q+1;/p-1/t16-,17+,18?,19?,21?;
    SMILES Code: O=C(OC1C[[email protected]]([N+]2(C)C(C)C)([H])CC[[email protected]]2([H])C1)C(C3=CC=CC=C3)CO.[Br-]
    SynonymsSch-1000; ipratropium bromide, Sch 1000;  Sch1000; trade names: Atrovent, Apovent, Ipraxa, Rinatec


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    In Vitro

    In vitro activity: Ipratropium bromide combined with Formoterol partially protects the lungs against the chronic inflammation and airspace enlargement by reducing neutrophilic infiltration possibly via the inhibition of MMP-9 activity. Ipratropium bromide (1 nM) significantly increases [Ca(2+)](i), decreases forward scatter and increases annexin-V-binding. Ipratropium bromide treatment is followed by slight but significant increase of hemolysis. Ipratropium bromide triggers suicidal erythrocyte death or eryptosis, an effect mainly due to stimulation of Ca(2+)-entry.


    Cell Assay: Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine. Target: mAChR Ipratropium bromide, a nonselective muscarinic antagonist, is widely prescribed for the treatment of chronic obstructive pulmonary disease (COPD).

    In VivoIpratropium dry powder inhalation (DPI) at a dose of 2400 mg/horse is an effective bronchodilator in these horses at rest but it has little effect on the airway calibre during the recovery period. Ipratropium significantly attenuates the lung lesions associated with parenchyma inflammatory cell influx and congestion observed in the cadmium treated rats. Ipratropium bromide partially protects the lungs against the inflammation by reducing neutrophilic infiltration. Ipratropium is an antagonist for pre-junctional muscarinic inhibitory receptors on pulmonary parasympathetic nerves and also confirms its potent antagonist actions on post-junctional muscarinic receptors in the airway smooth muscle in the guinea-pig. Ipratropium decreases the maximal change in pleural pressure during tidal breathing (delta Pplmax) and pulmonary resistance (RL) and increases dynamic compliance (Cdyn) in horse. 
    Animal model Horses and pigs
    Formulation & Dosage 2400 mg/horse
    ReferencesEur J Pharmacol. 2010 Nov 25;647(1-3):178-87; Equine Vet J. 1999 Jan;31(1):20-4. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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