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    Imidapril HCl (TA-6366)
    Imidapril HCl (TA-6366)

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1789
    CAS #: 89396-94-1Purity ≥98%

    Description: Imidapril HCl (TA-6366; TA-6366; Tanatril), the hydrochloride salt of imidapril, is a potent angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, approved in 1993 for use as an antihypertensive drug and for the treatment of chronic heart failure. As a prodrug, imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

    References: J Cardiovasc Pharmacol. 2014 Jun;63(6):528-32. 

    Related CAS #: 89396-94-1 (HCl)   89371-37-9 (free)

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    Molecular Weight (MW)441.91 
    FormulaC20H27N3O6.HCl 
    CAS No.89396-94-1 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 88 mg/mL (199.1 mM) 
    Water: 54 mg/mL (122.19 mM)
    Ethanol: 29 mg/mL (65.6 mM) 
    SMILESO=C([[email protected]](CN1C)N(C([[email protected]@H](N[[email protected]](C(OCC)=O)CCC2=CC=CC=C2)C)=O)C1=O)O.[H]Cl
    SynonymsTA-6366; TA 6366; TA6366; 


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