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    Ilorasertib
     Ilorasertib

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4411
    CAS #: 1227939-82-3 Purity ≥98%

    Description: Ilorasertib (also known as ABT-348) is a potent, novel, orally bioavailable and ATP-competitive multi-kinase inhibitor with IC50s for inhibiting binding Aurora B (7 nM), C (1 nM), and A (120 nM), and also inhibits RET tyrosine kinase, PDGFRβ, and Flt1 with IC50s of 7 nM, 3 nM and 32 nM. Ilorasertib is currently in Phase I clinical trials. Based on its unique spectrum of activity, ABT 348 was evaluated and found effective in representative solid tumor (HT1080 and MiaPaCa, tumor stasis) and hematological malignancy (RS4;11, regression) xenografts. These results provide the rationale for clinical assessment of ABT-348 as a therapeutic agent in the treatment of cancer.

    References: Bioorg Med Chem Lett. 2012 May 1;22(9):3208-12.J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.


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     Ilorasertib

    Name: Ilorasertib
    CAS#: 1227939-82-3
    Chemical Formula: C25H21FN6O2S
    Exact Mass: 488.14307
    Molecular Weight: 488.54
    Elemental Analysis: C, 61.46; H, 4.33; F, 3.89; N, 17.20; O, 6.55; S, 6.56
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: ABT348; ABT-348; ABT 348; Abbott 968660;
    IUPAC/Chemical Name: 1-(4-(4-amino-7-(1-(2-hydroxyethyl)-1H-pyrazol-4-yl)thieno[3,2-c]pyridin-3-yl)phenyl)-3-(3-fluorophenyl)urea
    InChi Key: WPHKIQPVPYJNAX-UHFFFAOYSA-N
    InChi Code: InChI=1S/C25H21FN6O2S/c26-17-2-1-3-19(10-17)31-25(34)30-18-6-4-15(5-7-18)21-14-35-23-20(12-28-24(27)22(21)23)16-11-29-32(13-16)8-9-33/h1-7,10-14,33H,8-9H2,(H2,27,28)(H2,30,31,34)
    SMILES Code: O=C(NC1=CC=CC(F)=C1)NC2=CC=C(C3=CSC4=C3C(N)=NC=C4C5=CN(CCO)N=C5)C=C2


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