![Ibotenic Acid [(RS)-Ibotenic acid; DL-Ibotenic acid]](/upload/0201/6374167693676059941396864166.png)
| Size | Price | Stock | Qty |
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| 5mg |
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| 10mg |
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| 25mg |
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| 50mg |
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| 100mg |
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| Other Sizes |
Purity: ≥98%
Ibotenic Acid [(RS)-Ibotenic acid; DL-Ibotenic acid] is a highly potent excitatory amino acid agonist with activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites. Ibotenic Acid causes motor depression, ataxia, and changes in mood. Ibotenic Acid is also a neurotoxin.
| ln Vitro |
In the central nervous system, amitanic acid (Ibo) operates on both NMDA and trans-ACPD receptors; however, Ibo toxicity has only been linked to NMDA receptor activation. When cortical neurons are exposed to amitanic acid for five minutes, the release of acid dehydrogenase into the culture medium indicates that the acid is hazardous (EC50=77.3±8 μM; n=5) [1].
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| References | |
| Additional Infomation |
Ibotenic acid is a non-protein α-amino acid with neurotoxic effects. It has been reported in Amanita gemmata, Amanita muscaria, and other organisms with relevant data. Ibotenic acid is a chemical compound naturally found in mushrooms such as Amanita muscaria and Amanita pantherina. It is a potent neurotoxin used as a brain-damaging agent and has been shown to have high neurotoxicity when directly injected into the brains of mice and rats. Ibotenic acid was initially isolated in the 1960s from Amanita ibotengutake, a Japanese mushroom very similar to Amanita pantherina. (L1141) Ibotenic acid is a neurotoxic isoxazole compound (similar to phycocyanine and muscarinic acid) found in Amanita mushrooms. It can cause motor inhibition, ataxia, and changes in mood, perception, and sensation, and is a potent excitatory amino acid agonist.
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| Molecular Formula |
C5H6N2O4
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|---|---|
| Molecular Weight |
158.11200
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| Exact Mass |
158.032
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| CAS # |
2552-55-8
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| PubChem CID |
1233
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| Appearance |
Light yellow to yellow solid powder
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| Density |
1.7±0.1 g/cm3
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| Boiling Point |
458.8±45.0 °C at 760 mmHg
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| Melting Point |
141-147 °C
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| Flash Point |
231.3±28.7 °C
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| Vapour Pressure |
0.0±1.2 mmHg at 25°C
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| Index of Refraction |
1.610
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| LogP |
-1.07
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| Hydrogen Bond Donor Count |
3
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| Hydrogen Bond Acceptor Count |
5
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| Rotatable Bond Count |
2
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| Heavy Atom Count |
11
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| Complexity |
235
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| Defined Atom Stereocenter Count |
0
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| InChi Key |
IRJCBFDCFXCWGO-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)
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| Chemical Name |
2-Amino-2-(3-oxo-1,2-oxazol-5-yl)acetic acid
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| Synonyms |
(RS)-Ibotenic acid DL-Ibotenic acid Ibotenate
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
H2O : ~5 mg/mL (~31.62 mM)
DMSO : ~5 mg/mL (~31.62 mM) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 0.5 mg/mL (3.16 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.5 mg/mL (3.16 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 5.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 0.5 mg/mL (3.16 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 8.67 mg/mL (54.84 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 6.3247 mL | 31.6236 mL | 63.2471 mL | |
| 5 mM | 1.2649 mL | 6.3247 mL | 12.6494 mL | |
| 10 mM | 0.6325 mL | 3.1624 mL | 6.3247 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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