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    L-Hyoscyamine (Daturine)
    L-Hyoscyamine (Daturine)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1200
    CAS #: 101-31-5Purity ≥98%

    Description: L-Hyoscyamine (Daturine), a natural tropane alkaloid and plant toxin, is the the levo-isomer of atropine and is used for controlling symptoms associated with disorders of the gastrointestinal (GI) tract. It is a secondary metabolite extracted from certain plants such as mandrake,  Solanaceae, henbane, angel's trumpets, jimsonweed, tomato, the sorcerers' tree, and deadly nightshade. It acts as a highly potent AChR inhibitor with IC50 of 7.5 nM. 

    References: Biochemistry. 1987 Dec 15;26(25):8175-82; Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8.

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    Molecular Weight (MW)289.37 
    FormulaC17H23NO3 
    CAS No.101-31-5 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 58 mg/mL (200.4 mM)
    Water: <1 mg/mL
    Ethanol: 58 mg/mL (200.4 mM)
    Solubility (In vivo)30% Propylene glycol, 5% Tween 80, 65% D5W: 5 mg/mL 
    SynonymsDaturine 


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    In Vitro

    In vitro activity: -hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements. R-(+)-hyoscyamine results in displacement of [3H]NMS binding to the muscarinic acetylcholine receptor subtypes (m1-m5) with pKi value of 8.67, 8.51, 7.46, 8.56 and 8.53, respectively. Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells. S-(-)-hyoscyamine enhances the forskolin-stimulated synthesis of cyclic AMP in rat cardiac (both atrial and ventricular) membranes by up to 24%.

    In VivoL-hyoscyamine (20 mg/kg) prolongs migrating myoelectric complex (MMC) cycle length from 17.6 min to 29.0 min in conscious rats. 
    Animal modelRat
    Formulation & DosageDissolved in saline; 20 mg/kg; i.v. injection
    References

    Biochemistry. 1987 Dec 15;26(25):8175-82; Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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