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Description: L-Hyoscyamine (Daturine), a natural tropane alkaloid and plant toxin, is the the levo-isomer of atropine and is used for controlling symptoms associated with disorders of the gastrointestinal (GI) tract. It is a secondary metabolite extracted from certain plants such as mandrake, Solanaceae, henbane, angel's trumpets, jimsonweed, tomato, the sorcerers' tree, and deadly nightshade. It acts as a highly potent AChR inhibitor with IC50 of 7.5 nM.
References: Biochemistry. 1987 Dec 15;26(25):8175-82; Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
In vitro activity: -hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements. R-(+)-hyoscyamine results in displacement of [3H]NMS binding to the muscarinic acetylcholine receptor subtypes (m1-m5) with pKi value of 8.67, 8.51, 7.46, 8.56 and 8.53, respectively. Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells. S-(-)-hyoscyamine enhances the forskolin-stimulated synthesis of cyclic AMP in rat cardiac (both atrial and ventricular) membranes by up to 24%.
Biochemistry. 1987 Dec 15;26(25):8175-82; Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8.
Purity ≥98%
COA
MSDS
NMR