| Size | Price | Stock | Qty |
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| 100mg |
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| 250mg |
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Purity: ≥98%
Homosalate is an organic chemical substance used as a UV filter in cosmetics and sunscreens to absorb UVB rays, shielding the skin from sun damage.
| ln Vitro |
Extracellular vesicles (EVs) released by Homosalate-treated cells increase a recipient epithelial tumor cell line's resistance to anchorage loss.[2]
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| Cell Assay |
For EV isolation, 6 × 106 MDA-MB-231 parental cells were seeded per 15 cm culture dish in an ideal number of dishes to produce 70 × 106, 27 × 106 or 50 × 106 secreting cells. After 24 hours, cells were washed once with PBS and then 15 ml of serum- and phenol-red-free Leibovitz's L-15 were added. In phenol-red-free, serum-free Leibovitz's L-15 medium, DMSO (0.1%), Homosalate (10 μM), or Bafilomycin A1 (100 nM) were added before the cells were incubated for 24 or 16 hours, respectively. The following day, cells were counted, and Trypan Blue was used to calculate the percentage of cell viability.
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| References |
| Molecular Formula |
C16H22O3
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|---|---|
| Molecular Weight |
262.35
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| Exact Mass |
262.1569
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| Elemental Analysis |
C, 73.25; H, 8.45; O, 18.30
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| CAS # |
118-56-9
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| Related CAS # |
Homosalate-d4
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| Appearance |
Liquid
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| SMILES |
CC1CC(CC(C1)(C)C)OC(=O)C2=CC=CC=C2O
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| InChi Key |
WSSJONWNBBTCMG-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H22O3/c1-11-8-12(10-16(2,3)9-11)19-15(18)13-6-4-5-7-14(13)17/h4-7,11-12,17H,8-10H2,1-3H3
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| Chemical Name |
(3,3,5-trimethylcyclohexyl) 2-hydroxybenzoate
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| Synonyms |
Homomenthyl
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~381.2 mM; Need ultrasonic)
H2O: <0.1 mg/mL (insoluble) |
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| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (9.53 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (9.53 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (9.53 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.8117 mL | 19.0585 mL | 38.1170 mL | |
| 5 mM | 0.7623 mL | 3.8117 mL | 7.6234 mL | |
| 10 mM | 0.3812 mL | 1.9059 mL | 3.8117 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT03582215 | Completed | Drug: Part 1: Cream Drug: Part 1: Lotion |
Systemic Exposure to Sunscreen Ingredients |
Food and Drug Administration (FDA) |
July 18, 2018 | Phase 1 |
| NCT01001975 | Completed | Drug: Sunscreen Test Code: V53-028 Drug: Sunscreen Test Code: V53-030 |
Sun Protection | Bayer | July 2009 | Phase 3 |
| NCT00530387 | Completed | Drug: 19 organic sunscreen filters and 5 topical NSAIDs |
Dermatitis, Photocontact | NHS Tayside | July 2008 |
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