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    Homatropine Methylbromide (Homatropine methobromide)
    Homatropine Methylbromide (Homatropine methobromide)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1198
    CAS #: 80-49-9Purity ≥98%

    Description: Homatropine Methylbromide (Homatropine methobromide), a quaternary ammonium salt of methylhomatropine and a peripherally acting anticholinergic medication, is potent muscarinic AChR antagonist used to treat duodenal or stomach ulcers or intestine problems. It can be used in combination with antacids or other medications to treat peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.  

    References: Eur J Pharmacol. 1982 May 7;80(1):11-7; J Med Toxicol. 2006 Dec;2(4):156-9.

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    Molecular Weight (MW)370.28 
    CAS No.80-49-9 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 74 mg/mL (199.8 mM) 
    Water: 74 mg/mL (199.8 mM) 
    Ethanol: 10 mg/mL (27.0 mM)
    Solubility (In vivo)Saline: 30 mg/mL 
    SynonymsHomatropine methobromide

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    In Vitro

    In vitro activity: Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs. Homatropine has similar affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses.

    In VivoHomatropine (20 mg/kg) prevents lethality in rats with dichlorvos poisoning with survive rate of 30% and time of death ranged between 4 and 12 minutes, while Homatropine (10 mg/kg) has no effect on preventing lethality. Homatropine [14C]methylbromide administrated rectal achieves higher and rapid peak plasma concentrations than by the other routes in rats whether HMB-14C is administered in a water-soluble suppository base or in aqueous solution, retained 28% of the 14C has been excreted in the urine while 56% remained in the large intestine after 12 hours. Unlabelled Homatropine methylbromide, given in rectal suppositories to anaesthetized rats, causes prompt blockade of the effects of vagal stimulation on pulse rate and of intravenous acetylcholine on blood pressure. 
    Animal modelSprague-Dawley rats 
    Formulation & DosageDissolved in saline;  20 mg/kg; Intramuscular (IM) injections 

    Eur J Pharmacol. 1982 May 7;80(1):11-7; J Med Toxicol. 2006 Dec;2(4):156-9. 

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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