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| 250mg |
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| 500mg |
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| 1g |
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| 2g |
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Purity: ≥98%
Homatropine Methylbromide (Homatropine methobromide), a quaternary ammonium salt of methylhomatropine and a peripherally acting anticholinergic medication, is potent muscarinic AChR antagonist used to treat duodenal or stomach ulcers or intestine problems. It can be used in combination with antacids or other medications to treat peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.
| ln Vitro |
When administered alone to guinea pigs, homotropine methylbromide (20 μM) results in a dose ratio of 259 in the atrium. Pork.
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| ln Vivo |
In this rat model of acute OC poisoning, pre-treatment with homotropine methylbromide (homotropine methobromide) (20 mg/kg) was as effective as atropine (10 mg/kg) in averting fatality.
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| References |
[1]. Sim MK et al. Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study. Clin Exp Hypertens. 1993 Mar;15(2):409-21.
[2]. Bryant SM et al. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2(4):156-9. [3]. Leung E et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol. 1982 May 7;80(1):11-7. |
| Molecular Formula |
C17H24NO3.BR
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| Molecular Weight |
370.28
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| CAS # |
80-49-9
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| Related CAS # |
Homatropine Bromide;51-56-9;Homatropine;87-00-3
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| SMILES |
[Br-].O(C(C([H])(C1C([H])=C([H])C([H])=C([H])C=1[H])O[H])=O)C1([H])C([H])([H])[C@]2([H])C([H])([H])C([H])([H])[C@]([H])(C1([H])[H])[N+]2(C([H])([H])[H])C([H])([H])[H]
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| Synonyms |
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
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| Solubility (In Vivo) |
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| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.7007 mL | 13.5033 mL | 27.0066 mL | |
| 5 mM | 0.5401 mL | 2.7007 mL | 5.4013 mL | |
| 10 mM | 0.2701 mL | 1.3503 mL | 2.7007 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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