My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Hexamethonium Bromide
    Hexamethonium Bromide

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1201
    CAS #: 55-97-0Purity ≥98%

    Description: Hexamethonium Bromide (Vegolysen; Esametina; Simpatoblock), a peripherally-acting and nondepolarizing neuromuscular blocker, is a selective antagonist of neuronal-type nicotinic AChR in ganglia that was used to treat chronic hypertension. But the use of Hexamethonium was discontinued due to the non-specificity of its action.

    References: Br J Pharmacol. 1984 Mar;81(3):519-31; Br J Pharmacol. 1997 Nov;122(6):1025-34.

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW)362.19 
    FormulaC12H30N2.2Br 
    CAS No.55-97-0 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL 
    Water: 73 mg/mL (201.55 mM) 
    Ethanol: <1 mg/mL
    Other infoChemical Name: N1,N1,N1,N6,N6,N6-hexamethylhexane-1,6-diaminium bromide

    InChi Key: FAPSXSAPXXJTOU-UHFFFAOYSA-L

    InChi Code: InChI=1S/C12H30N2.2BrH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2

    SMILES Code: C[N+](CCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]           

    SynonymsHexamethionium bromide; Vegolysen; Esametina; Simpatoblock; 


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide (50-200 μM) causes an increase in the amplitude of nerve-evoked endplate currents (e.p.cs) recorded in the presence of 0.6 μM tubocurarine. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM. Hexamethonium Bromide (200 μM) decreases the time constant of decay of both endplate currents (e.p.cs) (by ~25%) and miniature endplate currents (m.e.p.cs) (by ~20%) in the rat hemi-diaphragm muscle. At low frequencies of stimulation (0.5-2 Hz), Hexamethonium Bromide (200 μM) increases e.p.c. quantal content by 30-40%.

    In Vivo
    Animal model
    Formulation & Dosage
    References

    Br J Pharmacol. 1984 Mar;81(3):519-31; Br J Pharmacol. 1997 Nov;122(6):1025-34. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?