Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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Other Sizes |
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ln Vivo |
Herbacetin (oral; 20 mg/kg) in mice with obesity-associated insulin resistance (OIR) dramatically lowers body weight, blood glucose, plasma insulin, and HOMA-IR activity. In 0.5% DMSO, the herbacetin is dissolved [1]. Without appearing to be harmful, herbacetin (intraperitoneal injection; 0.4, 2, 10, or 20 mg/kg; BW) decreases the quantity and size of polyps in APCMin+ mice [2].
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References |
[1]. Veeramani C, et al. Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes. Chem Biol Interact. 2018 May 25;288:49-56.
[2]. Kim DJ, et al. Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity. Cancer Res. 2016 Mar 1;76(5):1146-1157. [3]. Qian J, Li Y, Zhang X, et al. Herbacetin Broadly Blocks the Activities of CYP450s by Different Inhibitory Mechanisms [published online ahead of print, 2021 Jun 11]. Planta Med. 2021;10.1055/a-1502-7131. [4]. Li L, Fan P, Chou H, Li J, Wang K, Li H. Herbacetin suppressed MMP9 mediated angiogenesis of malignant melanoma through blocking EGFR-ERK/AKT signaling pathway. Biochimie. 2019;162:198-207. |
Molecular Formula |
C15H10O7
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Molecular Weight |
302.2357
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Exact Mass |
302.04
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Elemental Analysis |
C, 59.61; H, 3.34; O, 37.05
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CAS # |
527-95-7
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Appearance |
Solid powder
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SMILES |
C1=CC(=CC=C1C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O)O)O)O
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InChi Key |
ZDOTZEDNGNPOEW-UHFFFAOYSA-N
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InChi Code |
InChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)14-13(21)12(20)10-8(17)5-9(18)11(19)15(10)22-14/h1-5,16-19,21H
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Chemical Name |
3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one
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Synonyms |
Herbacetin; 8-hydroxy Kaempferol; Isoarticulatidin
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~330.86 mM)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 3.3086 mL | 16.5431 mL | 33.0863 mL | |
5 mM | 0.6617 mL | 3.3086 mL | 6.6173 mL | |
10 mM | 0.3309 mL | 1.6543 mL | 3.3086 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.