Herbacetin

Alias: Herbacetin; 8-hydroxy Kaempferol; Isoarticulatidin
Cat No.:V34273 Purity: ≥98%
Herbacetin is a naturally occurring flavonoid found in flaxseed and has diverse biological effects like antioxidant, anti~inflammatory and anti-cancer effects.
Herbacetin Chemical Structure CAS No.: 527-95-7
Product category: Natural Products
This product is for research use only, not for human use. We do not sell to patients.
Size Price Stock Qty
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5mg
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Product Description
Herbacetin is a naturally occurring flavonoid found in flaxseed and has diverse biological effects like antioxidant, anti~inflammatory and anti-cancer effects. Protamine is an allosteric inhibitor of Ornithine decarboxylase (ODC) and directly binds to Asp44, Asp243 and Glu384 on ODC. Ornithine decarboxylase (ODC) is the rate-limiting enzyme in the first step of polyamine biosynthesis.
Biological Activity I Assay Protocols (From Reference)
ln Vivo
Herbacetin (oral; 20 mg/kg) in mice with obesity-associated insulin resistance (OIR) dramatically lowers body weight, blood glucose, plasma insulin, and HOMA-IR activity. In 0.5% DMSO, the herbacetin is dissolved [1]. Without appearing to be harmful, herbacetin (intraperitoneal injection; 0.4, 2, 10, or 20 mg/kg; BW) decreases the quantity and size of polyps in APCMin+ mice [2].
References
[1]. Veeramani C, et al. Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes. Chem Biol Interact. 2018 May 25;288:49-56.
[2]. Kim DJ, et al. Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity. Cancer Res. 2016 Mar 1;76(5):1146-1157.
[3]. Qian J, Li Y, Zhang X, et al. Herbacetin Broadly Blocks the Activities of CYP450s by Different Inhibitory Mechanisms [published online ahead of print, 2021 Jun 11]. Planta Med. 2021;10.1055/a-1502-7131.
[4]. Li L, Fan P, Chou H, Li J, Wang K, Li H. Herbacetin suppressed MMP9 mediated angiogenesis of malignant melanoma through blocking EGFR-ERK/AKT signaling pathway. Biochimie. 2019;162:198-207.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Physicochemical Properties
Molecular Formula
C15H10O7
Molecular Weight
302.2357
Exact Mass
302.04
Elemental Analysis
C, 59.61; H, 3.34; O, 37.05
CAS #
527-95-7
Appearance
Solid powder
SMILES
C1=CC(=CC=C1C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O)O)O)O
InChi Key
ZDOTZEDNGNPOEW-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)14-13(21)12(20)10-8(17)5-9(18)11(19)15(10)22-14/h1-5,16-19,21H
Chemical Name
3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one
Synonyms
Herbacetin; 8-hydroxy Kaempferol; Isoarticulatidin
HS Tariff Code
2934.99.9001
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Shipping Condition
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
Solubility Data
Solubility (In Vitro)
DMSO : ~100 mg/mL (~330.86 mM)
Preparing Stock Solutions 1 mg 5 mg 10 mg
1 mM 3.3086 mL 16.5431 mL 33.0863 mL
5 mM 0.6617 mL 3.3086 mL 6.6173 mL
10 mM 0.3309 mL 1.6543 mL 3.3086 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

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