Size | Price | Stock | Qty |
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1mg |
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5mg |
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10mg |
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Other Sizes |
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Purity: ≥98%
GSTO-IN-2 is a novel and potent glutathione S-transferase inhibitor with IC50s of 3.6, 16.3, and 1.4 μM for GSTA2, GSTM1, and GSTP1-1.
ln Vitro |
In Ref, chemical 3 is GSTO-IN-2. By deactivating the GST isoenzyme, GSTO-IN-2 demonstrated synergy with chemotherapeutic medicines against two cell lines of breast cancer. At 50 μM GSTO-IN-2, the maximum reduction in cisplatin-induced cell viability was noted, reaching up to 640% in comparison with MCF-7 and up to 270% in comparison with MDA-MB-231. The activity-inhibitory action of thiotepa is enhanced by GSTO-IN-2 (25 and 50 μM), which can inhibit MCF-7 by up to 170-320% and MDA-MB-231 by up to 180-270%. [1].
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References |
[1]. Chang KH, et al. Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors. Chem Commun (Camb). 2006 Feb 14;(6):629-31.
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Molecular Formula |
C33H52N2O9
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Molecular Weight |
620.773990631104
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CAS # |
1202710-57-3
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SMILES |
C[C@]12CC[C@]3([H])[C@]4(CC[C@@H](OC(=O)[C@H](CC(=O)O)NC(=O)CC[C@H](N)C(=O)O)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@]2([H])[C@H](C)CCC(=O)O)C
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Synonyms |
GSTO-IN-2; GSTO IN2; GSTO IN-2
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~100 mg/mL (~161.09 mM)
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Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 1.6109 mL | 8.0545 mL | 16.1090 mL | |
5 mM | 0.3222 mL | 1.6109 mL | 3.2218 mL | |
10 mM | 0.1611 mL | 0.8055 mL | 1.6109 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.