| Size | Price | Stock | Qty |
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| 10mg |
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| 25mg |
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| Targets |
Gomisin N targets multiple pathways and enzymes. It activates AMPK, a key regulator of cellular energy homeostasis. It induces apoptosis, likely through the modulation of apoptotic pathways. Its anti-inflammatory effects are mediated by modifying the serotonergic and GABAergic systems. It also exhibits anti-hepatitis activity. Its diverse activities are attributed to its ability to interact with multiple cellular targets.
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| ln Vitro |
In vitro, Gomisin N induces apoptosis in a variety of cells. It activates AMPK. It has been shown to have anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, anti-melanogenesis, and anticancer activities. It also exhibits anti-hepatitis activity. The compound's ability to modulate multiple pathways makes it a valuable tool for studying various diseases.
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| ln Vivo |
In vivo, Gomisin N is orally active. It has been shown to produce beneficial sedative and hypnotic effects in animal models. It also has anti-tumor effects. Its anti-inflammatory, anti-cancer, and neuroprotective effects have been reported. It may be utilized in allergy-related research.
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| Enzyme Assay |
Gomisin N has a molecular weight of 400.46 g/mol and a molecular formula of C₂₃H₂₈O₆. It has a melting point of 105-107°C. It should be stored at 2-8°C, sealed, and away from light. As a lignan, it is expected to have moderate lipophilicity and good oral bioavailability. Detailed pharmacokinetic parameters are available from preclinical studies.
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| Cell Assay |
The toxicity profile of Gomisin N is not extensively detailed in the provided search results. As a natural product from Schisandra chinensis, which has a long history of use, it is generally considered to have a good safety profile. However, comprehensive toxicological studies are required for therapeutic development. It is not intended for human therapeutic use without further development.
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| Animal Protocol |
Gomisin N is an orally active lignan from Schisandra chinensis with diverse biological activities, including anti-inflammatory, antioxidant, anti-cancer, and sedative effects. It induces apoptosis and activates AMPK. It is also known as 戈米辛N. It is not approved for clinical use and is intended for research purposes only.
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| References |
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| Additional Infomation |
(+)-Schisandrin B is an organic heterotetracyclic compound found in Schisandra chinensis and Schisandra chinensis. It possesses nephroprotective, apoptosis-inhibiting, plant metabolism-enhancing, anti-asthmatic, antioxidant, anti-inflammatory, neuroprotective, hepatoprotective, and lipid-lowering effects. It is an organic heterotetracyclic compound belonging to the aromatic ether, oxoheterocyclic, and cyclic acetal groups. Schisandrin N has been reported to exist in Schisandra chinensis, closely related Schisandra chinensis, and other organisms with relevant data. See also: Schisandrin B (note moved to).
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| Molecular Formula |
C23H28O6
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|---|---|
| Molecular Weight |
400.4648
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| Exact Mass |
400.188
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| CAS # |
69176-52-9
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| Related CAS # |
69176-52-9
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| PubChem CID |
158103
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| Appearance |
White to off-white solid
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| Density |
1.148±0.06 g/cm3
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| Boiling Point |
545.0±50.0 °C at 760 mmHg
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| Melting Point |
104-108 ºC
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| Flash Point |
220.4±30.0 °C
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| Vapour Pressure |
0.0±1.4 mmHg at 25°C
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| Index of Refraction |
1.543
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| LogP |
6.46
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| Hydrogen Bond Donor Count |
0
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| Hydrogen Bond Acceptor Count |
6
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| Rotatable Bond Count |
4
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| Heavy Atom Count |
29
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| Complexity |
544
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| Defined Atom Stereocenter Count |
2
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| SMILES |
O1C([H])([H])OC2=C1C([H])=C1C(=C2OC([H])([H])[H])C2=C(C(=C(C([H])=C2C([H])([H])[C@@]([H])(C([H])([H])[H])[C@@]([H])(C([H])([H])[H])C1([H])[H])OC([H])([H])[H])OC([H])([H])[H])OC([H])([H])[H]
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| InChi Key |
RTZKSTLPRTWFEV-OLZOCXBDSA-N
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| InChi Code |
InChI=1S/C23H28O6/c1-12-7-14-9-16(24-3)20(25-4)22(26-5)18(14)19-15(8-13(12)2)10-17-21(23(19)27-6)29-11-28-17/h9-10,12-13H,7-8,11H2,1-6H3/t12-,13+/m1/s1
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| Chemical Name |
(9R,10S)-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaene
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| Synonyms |
Gomisin N
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO: ~100 mg/mL (~249.7 mM)
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|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (6.24 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (6.24 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4971 mL | 12.4856 mL | 24.9713 mL | |
| 5 mM | 0.4994 mL | 2.4971 mL | 4.9943 mL | |
| 10 mM | 0.2497 mL | 1.2486 mL | 2.4971 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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