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    GNE-0946
    GNE-0946

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4555
    CAS #: 1677667-24-1Purity ≥98%

    Description: GNE-0946 is a novel, potent and selective RORγ( RORc) inverse agonist with an EC50 value of 4 nM in HEK-293 cells. The nuclear receptor (NR) retinoic acid receptor-related orphan receptor gamma (RORγ, RORc, or NR1F3) is a promising target for the treatment of autoimmune diseases. RORc is a critical regulator in the production of the pro-inflammatory cytokine interleukin-17. GNE-0946 displayed >300-fold selectivity for RORc over the other ROR family members, PPARγ, and NRs in our cellular selectivity panel. The favorable potency, selectivity, and physiochemical properties of GNE-0946 and GNE-6468, in addition to their potent suppression of IL-17 production in human primary cells, support their use as chemical biology tools to further explore the role of RORc in human biology.

    References:  2015 Aug 1;25(15):2907-12. 


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    GNE-0946Name: GNE-0946
    CAS#: 1677667-24-1
    Chemical Formula: C22H12ClF3N2O4
    Exact Mass: 460.0438
    Molecular Weight: 460.79
    Elemental Analysis: C, 57.35; H, 2.63; Cl, 7.69; F, 12.37; N, 6.08; O, 13.89
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: GNE0946; GNE 0946; GNE-0946
    IUPAC/Chemical Name: 4-[3-(2-Chloro-6-trifluoromethyl-benzoyl)-imidazo[1,5-a]pyridin-1-yl]-2-hydroxy-benzoic acid
    InChi Key: UAAUZNSONHHQQI-UHFFFAOYSA-N
    InChi Code: InChI=1S/C22H12ClF3N2O4/c23-14-5-3-4-13(22(24,25)26)17(14)19(30)20-27-18(15-6-1-2-9-28(15)20)11-7-8-12(21(31)32)16(29)10-11/h1-10,29H,(H,31,32)
    SMILES Code: O=C(O)C1=CC=C(C2=C3C=CC=CN3C(C(C4=C(C(F)(F)F)C=CC=C4Cl)=O)=N2)C=C1O


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