| Size | Price | Stock | Qty |
|---|---|---|---|
| 500mg |
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| Other Sizes |
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| ln Vitro |
The DPPH antioxidant activity of glucosesamine sulfate (also known as D-glucosamine sulfate) is dose-dependent [2]. A four-hour short-term treatment with glucosamine sulfate can decrease the phosphorylation of translation-related proteins p70S6K and S6 and inhibit HIF-1α at the protein level [3]. In renal cells treated with TGF-β1 and blocked kidneys, glucosesamine sulfate dramatically lowers renal expression of fibronectin, type I collagen, and α-smooth muscle actin [4].
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|---|---|
| References |
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| Additional Infomation |
Glucosamine Sulfate is an amino sugar (2-amino, 2-deoxyglucose) in cell membranes, Glucosamine Sulfate is believed to play a role in cartilage formation and repair. Long-term glucosamine sulfate treatment retards progression of knee osteoarthritis; the mechanism appears to involve glucosamine's role as an essential substrate for glycosaminoglycans and hyaluronic acid, needed for formation of the joint proteoglycan structural matrix. (NCI04)
See also: Glucosamine Sulfate (annotation moved to). |
| Molecular Formula |
C6H15NO9S
|
|---|---|
| Molecular Weight |
277.24
|
| Exact Mass |
277.046
|
| CAS # |
29031-19-4
|
| Related CAS # |
Glucosamine;3416-24-8;Glucosamine hydrochloride;66-84-2
|
| PubChem CID |
115046
|
| Appearance |
White to off-white solid powder
|
| Density |
1.563g/cm3
|
| Boiling Point |
449.9ºC at 760mmHg
|
| Melting Point |
176°C
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| Flash Point |
225.9ºC
|
| Vapour Pressure |
5.53E-10mmHg at 25°C
|
| Hydrogen Bond Donor Count |
7
|
| Hydrogen Bond Acceptor Count |
10
|
| Rotatable Bond Count |
5
|
| Heavy Atom Count |
17
|
| Complexity |
223
|
| Defined Atom Stereocenter Count |
4
|
| SMILES |
S(=O)(=O)(O[H])O[H].O([H])[C@]([H])([C@@]([H])(C([H])([H])O[H])O[H])[C@@]([H])([C@]([H])(C([H])=O)N([H])[H])O[H]
|
| InChi Key |
FGNPLIQZJCYWLE-BTVCFUMJSA-N
|
| InChi Code |
InChI=1S/C6H13NO5.H2O4S/c7-3(1-8)5(11)6(12)4(10)2-9;1-5(2,3)4/h1,3-6,9-12H,2,7H2;(H2,1,2,3,4)/t3-,4+,5+,6+;/m0./s1
|
| Chemical Name |
(2R,3R,4S,5R)-2-amino-3,4,5,6-tetrahydroxyhexanal;sulfuric acid
|
| Synonyms |
D-Glucosamine sulphateGlucosamine sulphateGevoloxGlucosamine sulfate
|
| HS Tariff Code |
2934.99.9001
|
| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
|
| Solubility (In Vitro) |
H2O : ~125 mg/mL (~450.86 mM)
|
|---|---|
| Solubility (In Vivo) |
Solubility in Formulation 1: 100 mg/mL (360.69 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.
(Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.6070 mL | 18.0349 mL | 36.0698 mL | |
| 5 mM | 0.7214 mL | 3.6070 mL | 7.2140 mL | |
| 10 mM | 0.3607 mL | 1.8035 mL | 3.6070 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
| NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
| NCT06200415 | COMPLETED | Drug: Glucosamine Sulfate Drug: Ginger Oil |
Periodontal Pocket | Ain Shams University | 2022-11-08 | Phase 2 |
| NCT03936192 | WITHDRAWN | Drug: glucosamine sulphate 1500mg and meloxicam 15mg Drug: Glucosamine sulfate 1500mg and chondroitin sulfate 1200mg Drug: Placebos |
Knee Osteoarthritis | Eurofarma Laboratorios S.A. | 2019-01 | Phase 3 |
| NCT00251069 | COMPLETED | Drug: Glucosamine sulphate | Osteoarthritis | Slidgigtinstituttet | 2005-04 | Phase 4 |
| NCT02214095 | TERMINATED | Drug: glucosamine sulphate Drug: lactose capsules |
Chronic Periodontitis | Ain Shams University | 2012-01 | Early Phase 1 |
| NCT00513422 | UNKNOWN STATUS | Dietary Supplement: Glucosamine sulphate and chondroitin Dietary Supplement: Glucosamine sulphate Dietary Supplement: Chondroitin sulphate Dietary Supplement: Placebo capsules for glucosamine and chondroitin |
Osteoarthritis, Knee | University of Sydney | 2007-10 | Phase 4 |
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