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    GDC-0326
    GDC-0326

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4526
    CAS #: 1282514-88-8Purity ≥98%

    Description: GDC-0326 is a novel, potent and selective PI3Kα (α-Isoform of Phosphoinositide 3-Kinase) inhibitor with a Ki of 0.2 nM. Inhibitors of the class I phosphoinositide 3-kinase (PI3K) isoform PI3Kα have received substantial attention for their potential use in cancer therapy. Despite the particular attraction of targeting PI3Kα, achieving selectivity for the inhibition of this isoform has proved challenging. GDC-0326 exhibits high selectivity over other kinases. GDC-0326 has low plasma CL in human. Within the PI3 kinase family, there are four class I PI3K isoforms (α, β, δ, and γ). Of these isoforms, PI3Kα is the most commonly associated with cancers.

    References:  2016 Feb 11;59(3):985-1002.


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    GDC-0326

    Name: GDC-0326
    CAS#: 1282514-88-8
    Chemical Formula: C19H22N6O3
    Exact Mass: 382.1753
    Molecular Weight: 382.424
    Elemental Analysis: C, 59.67; H, 5.80; N, 21.98; O, 12.55
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: GDC-0326; GDC 0326; GDC0326; CAS#1282514-88-8
    IUPAC/Chemical Name: (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide
    InChi Key: SIKYDKLGPWRPMZ-LBPRGKRZSA-N
    InChi Code: InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3)17(20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1
    SMILES Code: C[[email protected]](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O


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