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    Inavolisib (GDC-0077)
     Inavolisib (GDC-0077)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V4528
    CAS #: 2060571-02-8Purity ≥98%

    Description:  Inavolisib (RG6114; GDC0077), extracted from patent WO 2017001645 A1, formula I, is a novel, potent and orally bioavailable PI3K inhibitor with potential anticancer activity. It acts by blocking PI3K which is overactive in cancer. Inhibition of PI3K prevents the activation of the PI3K-mediated signaling pathway and results in the inhibition of growth and survival of PI3K-overexpressing tumor cells.

    References: WO 2017001645 A1


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    GDC-0077

    Name: GDC-0077
    CAS#: 2060571-02-8
    Chemical Formula: C18H19F2N5O4
    Exact Mass: 407.1405
    Molecular Weight: 407.3778 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Technical InformationSynonym: GDC-0077; RG-6114; GDC 0077; RG 6114; GDC0077; RG6114
    Chemical Name: (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide
    InChi Key: SGEUNORSOZVTOL-CABZTGNLSA-N
    InChi Code: InChI=1S/C18H19F2N5O4/c1-9(16(21)26)22-10-2-3-11-13(6-10)28-5-4-24-7-14(23-17(11)24)25-12(15(19)20)8-29-18(25)27/h2-3,6-7,9,12,15,22H,4-5,8H2,1H3,(H2,21,26)/t9-,12-/m0/s1
    SMILES Code: C[[email protected]@H](C(N)=O)NC1=CC=C(C2=NC(N3[[email protected]](C(F)F)COC3=O)=CN2CCO4)C4=C1


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    Inavolisib (GDC0077), extracted from patent WO 2017001645 A1, formula I, is a novel, potent and orally bioavailable PI3K inhibitor with potential anticancer activity. It acts by blocking PI3K which is overactive in cancer. Inhibition of PI3K prevents the activation of the PI3K-mediated signaling pathway and results in the inhibition of growth and survival of PI3K-overexpressing tumor cells.

    References: WO 2017001645 A1


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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