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    Galanthamine HBr
    Galanthamine HBr

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1204
    CAS #: 1953-04-4Purity ≥98%

    Description: Galanthamine HBr (Razadyne, Reminyl), the hydrobromide salt of Galanthamine, is a centrally active and long-acting AChE/acetylcholinesterase inhibitor approved for the treatment of cognitive decline in Alzheimer's disease and various other memory impairments. It inhibits AChE with an IC50 of 0.35 μM, and shows > 50-fold selectivity over butyryl-cholinesterase. 

    References: Eur J Clin Chem Clin Biochem. 1991 Aug;29(8):487-92; J Pharmacol Exp Ther. 2007 Aug;322(2):591-9.

    Related CAS No.: 134332-50-6 (Galanthamine N-Oxide)

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    Molecular Weight (MW)368.27 
    FormulaC17H21NO3.HBr 
    CAS No.1953-04-4 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: <1 mg/mL 
    Water: 36 mg/mL (97.8 mM)
    Ethanol: <1 mg/mL 
    Solubility (In vivo)Saline: 20 mg/mL
    SynonymsGalantamine hydrobromide


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    In Vitro

    In vitro activity: Galanthamine has been demonstrated to have an IC50 of 14 nM and 15 nM on AChE in post-mortem human brain frontal cortex and the hippocampus region. Red-cell cholinesterase activity in blood samples from the neurosurgery patients is 10 times more strongly inhibited by Galanthamine in brain tissue samples. Galanthamine (1 μM) activates single channels with conductance's of 18 and 30 pS in outside-out patches excised from dexamethasone mouse fibroblasts (M10 cells). Galanthamine acts as noncompetitive nicotinic receptor agonists' on clonal rat pheochromocytoma (PC12) cells. Galanthamine (50 μM) activates single-channel currents in outside-out patches excised from clonal PC12 cells.

    In VivoGalantamine significantly increases the number of living pyramidal neurons after ischemia-reperfusion injury. Galantamine significantly reduces TUNEL, active caspase-3, and SOD-2 immunoreactivity. The nicotinic antagonist mecamylamine blockes the protective effects of galantamine. The neuroprotective effects of galantamine are preserved even when first administered at 3 hours postischemia. 
    Animal modelGerbils 
    Formulation & DosageDissolved in 0.9% NaCl saline solution; 10 mg/kg; s.c. injection
    References

    Eur J Clin Chem Clin Biochem. 1991 Aug;29(8):487-92; J Pharmacol Exp Ther. 2007 Aug;322(2):591-9.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Galanthamine HBr

    Galantamine (1 and 10 mg/kg), given 24 h before ischemia, significantly reduced the number of TUNEL- and active caspase-3-positive pyramidal neurons in CA1. J Pharmacol Exp Ther. 2007 Aug;322(2):591-9. 
     

    Galanthamine HBr

    Galantamine (10 mg/kg) administered 3 h postischemia afforded neuroprotection and reduced DNA fragmentation, active caspase-3, and SOD-2. J Pharmacol Exp Ther. 2007 Aug;322(2):591-9. 
     

    Galanthamine HBr

    Spatial memory recovery after 10 mg/kg galantamine administered 3 h postischemia. J Pharmacol Exp Ther. 2007 Aug;322(2):591-9.  


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