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| 5mg |
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| 10mg |
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| 25mg |
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| 100mg |
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FOY 251 mesylate is a Camostat metabolite with anti-proteolytic activity, and acts as a proteinase inhibitor. It was found to be successful in the cellullar assay in combating SARS-CoV-2 infection. The management and avoidance of allergies are further uses for it.
| ln Vitro |
FOY-251 inhibits prostasin's protease activity and dose-dependently reduces equivalent current (Ieq) in M-1 cells in vitro.[1]
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| ln Vivo |
FOY-251 increases the plasma and circulating levels of FGF21 of transcription are maintained with the induction of liver integrated stress response (ISR) transcription target genes up to one week of treatment in both ob/ob and lean mice; when administered to DIO mice, the levels of FGF21 in the plasma also increase.[3]
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| Enzyme Assay |
M-1 cells were cultivated on a semi-permeable membrane, subjected to a 24-hour serum deprivation, and treated from the apical side with either 0.01–10 μM FOY-251 or 0.01–1 μM camostat mesilate. Transepithelial voltage (Vte) and resistance (Rte) were measured using a volt-ohm meter following a 24-hour incubation period. Ieq was calculated as the ratio of Vte to Rte and was normalized by dividing it by the active membrane's surface area (113 mm2).
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| Animal Protocol |
Male ob/ob mice, lean and diet-induced obese (DIO) C57BL/6 mice
0.8 mg/g food p.o. |
| References |
| Molecular Formula |
C17H19N3O7S
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|---|---|
| Molecular Weight |
409.41366
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| Exact Mass |
409.09
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| Elemental Analysis |
C, 49.87; H, 4.68; N, 10.26; O, 27.35; S, 7.83
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| CAS # |
71079-09-9
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| Related CAS # |
FOY 251 free base;71079-08-8
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| Appearance |
Solid powder
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| SMILES |
CS(=O)(=O)O.C1=CC(=CC=C1CC(=O)O)OC(=O)C2=CC=C(C=C2)N=C(N)N
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| InChi Key |
JXMOPIDYHUYOED-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C16H15N3O4.CH4O3S/c17-16(18)19-12-5-3-11(4-6-12)15(22)23-13-7-1-10(2-8-13)9-14(20)21;1-5(2,3)4/h1-8H,9H2,(H,20,21)(H4,17,18,19);1H3,(H,2,3,4)
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| Chemical Name |
2-[4-[4-(diaminomethylideneamino)benzoyl]oxyphenyl]acetic acid;methanesulfonic acid
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| Synonyms |
FOY-251 mesylate; FOY 251; FOY-251; FOY251
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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| Solubility (In Vitro) |
DMSO : ~20 mg/mL (~48.85 mM)
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| Solubility (In Vivo) |
Solubility in Formulation 1: 2 mg/mL (4.89 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2 mg/mL (4.89 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2 mg/mL (4.89 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4425 mL | 12.2127 mL | 24.4254 mL | |
| 5 mM | 0.4885 mL | 2.4425 mL | 4.8851 mL | |
| 10 mM | 0.2443 mL | 1.2213 mL | 2.4425 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration： mg/mL；
Method for preparing DMSO stock solution： mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:：Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O，mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
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