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    Fluticasone propionate
    Fluticasone propionate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1702
    CAS #: 80474-14-2Purity ≥98%

    Description: Fluticasone Propionate (formerly CCI187881; CCI 187881; Cutivate, Flixonase, Flixotide, Flonase, Flovent) is a potent and synthetic glucocorticoid medication approved as a nasal spray for use in the treatment of non-allergic and allergic rhinitis. Fluticasone propionate belongs to a class of drugs known as corticosteroids (glucocorticoids) and has been used to treat asthma, allergic rhinitis, nasal polyps, various skin disorders and Crohn's disease and ulcerative colitis. It is also used to treat eosinophilic esophagitis. 

    References: Int Immunol. 2005 Nov;17(11):1473-81; Vet Immunol Immunopathol. 2002 Mar;85(3-4):147-58. 

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    Molecular Weight (MW)500.57
    CAS No.80474-14-2
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (199.8 mM)
    Water:<1 mg/mL
    Ethanol: 5 mg/mL (10.0 mM)
    Other infoChemical Name: (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
    InChi Code: InChI=1S/C25H31F3O5S/c1-5-20(31)33-25(21(32)34-12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15+,16+,18+,19+,22+,23+,24+,25+/m1/s1
    SMILES Code: CCC(O[[email protected]]1(C(SCF)=O)[[email protected]](C)C[[email protected]@H]2[[email protected]]1(C)C[[email protected]](O)[[email protected]@]3(F)[[email protected]]2C[[email protected]](F)C4=CC(C=C[[email protected]@]43C)=O)=O
    SynonymsCCI-187881; fluticasone Propionate, CCI187881; CCI 187881; Cutivate, Flixonase, Flixotide, Flonase, Flovent

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    In Vitro

    In vitro activity: Fluticasone propionate (1 pM) inhibits the constitutive and TGF-beta-induced expression of alpha-SMA in human lung myofibroblasts. Fluticasone propionate blocks the TNF-alpha-induced nuclear translocation of the pro-inflammatory transcription factor NF-kappaB in human lung myofibroblasts. Fluticasone propionate inhibits in lung myofibroblasts, at a very early stage of differentiation, the activation of Janus kinase/STAT pathways induced by IL-13 (tyrosine kinase 2, STAT1, STAT3, STAT6, mitogen-activated protein kinase). Fluticasone propionate still displays a potential anti-inflammatory activity even if it only inhibits tyrosine kinase 2 phosphorylation in mildly or fully differentiated myofibroblastic cultures. Fluticasone propionate inhibits constitutive and TGF-beta-induced expression of alpha-smooth muscle actin, the main marker of myofibroblastic differentiation, both in very early and in mild differentiated myofibroblasts. Fluticasone propionate displays an additional powerful anti-inflammatory effect, decreasing nuclear translocation of NF-kappaB independent of the degree of myofibroblastic differentiation. Fluticasone propionate inhibits allergen-induced T-cell proliferation, expression of IL-3, IL-5 and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent fashion. Fluticasone propionate has the potential markedly to inhibit allergen-induced T-cell production of asthma-relevant cytokines.  

    In VivoFluticasone propionate administrated after induction of a severe heaves exacerbation results in complete resolution of clinical signs, normalization of pulmonary function tests, and significant decrease in bronchoalveolar lavage (BAL) neutrophilia in horse. 
    Animal modelHorse
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    ReferencesInt Immunol. 2005 Nov;17(11):1473-81; Vet Immunol Immunopathol. 2002 Mar;85(3-4):147-58.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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