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    Fluorometholone Acetate
    Fluorometholone Acetate

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1715
    CAS #: 3801-06-7Purity ≥98%

    Description: Fluorometholone Acetate (also known as NSC 47438) is a synthetic corticosteroid, commonly used as eye drops in the treatment of steroid responsive inflammatory conditions of the eye. Hourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus.

    References: Arch Ophthalmol. 1982 Apr;100(4):640-1.

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    Molecular Weight (MW)418.5 
    FormulaC24H31FO5 
    CAS No.3801-06-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 84 mg/mL (200.7 mM) 
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: 9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 17-acetate

    InChi Key: YRFXGQHBPBMFHW-SBTZIJSASA-N

    InChi Code: 1S/C24H31FO5/c1-13-10-19-17-7-9-23(14(2)26,30-15(3)27)22(17,5)12-20(29)24(19,25)21(4)8-6-16(28)11-18(13)21/h6,8,11,13,17,19-20,29H,7,9-10,12H2,1-5H3/t13-,17-,19-,20-,21-,22-,23-,24-/m0/s1

    SMILES Code: C[[email protected]]1C[[email protected]]2[[email protected]@H]3CC[[email protected]@]([[email protected]]3(C[[email protected]@H]([[email protected]@]2([[email protected]@]4(C1=CC(=O)C=C4)C)F)O)C)(C(=O)C)OC(=O)C

    SynonymsNSC47438; AI352814; NSC 47438; AI352814; NSC-47438; AI 3-52814; Flarex, Fluorometholone 17-acetate, U 17,323; U-17,323


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    In Vitro

    In vitro activity: Fluorometholone Acetate is a synthetic corticosteroid, used in the treatment of steroid responsive inflammatory conditions of the eye.

    In VivoHourly topical administration of the drug suspension produces an average reduction of 46.8% in the polymorphonuclear leukocytes invading the corneal stroma. In the cornea, fluorometholone acetate appears to have a greater efficacy, as compared to fluorometholone alcohol, for reducing the number of leukocytes invading that tissue following an inflammatory stimulus. Animal toxicity studies of fluorometholone, including acute intraperitoneal LD50s in mice and rats, subacute oral toxicity in rats and dogs, and subacute topical ocular toxicity in rabbits have demonstrated the safety of this drug for human use. 
    Animal modelmice and rats
    Formulation & Dosagei.p.
    References

    Arch Ophthalmol. 1982 Apr;100(4):640-1. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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