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    Fluocinonide (Vanos)
    Fluocinonide (Vanos)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1707
    CAS #: 356-12-7 Purity ≥98%

    Description: Fluocinonide (trade names: Topsyn, Vanos, Lonide) is a potent glucocorticoid/corticosteroid that is used topically as an anti-inflammatory agent for the treatment of skin disorders such as seborrhoeic dermatitis and eczema. Fluocinonide cream has a lower potential to produce atrophic changes of the skin than either clobetasol cream or clobetasol propionate foam. It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort. Fluocinonide belongs to the so-called 'high-potency' (second-highest rank) topical corticosteroid.

    References: J Drugs Dermatol. 2008 Jan;7(1):28-32; J Drugs Dermatol. 2008 Jan;7(1):28-32.

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    Molecular Weight (MW)494.52 
    FormulaC26H32F2O7 
    CAS No.356-12-7 
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 99 mg/mL (200.2 mM) 
    Water: <1 mg/mL
    Ethanol: N/A
    Other infoChemical Name: 2-((2S,6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-2,6b-difluoro-7-hydroxy-6a,8a,10,10-tetramethyl-4-oxo-2,4,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-1H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-8b-yl)-2-oxoethyl acetate
    InChi Key: WJOHZNCJWYWUJD-IUGZLZTKSA-N
    InChi Code: InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1
    SMILES Code: CC(OCC([[email protected]@]12[[email protected]](OC(C)(C)O2)C[[email protected]@H]3[[email protected]]1(C)C[[email protected]](O)[[email protected]@]4(F)[[email protected]]3C[[email protected]](F)C5=CC(C=C[[email protected]@]54C)=O)=O)=O
    SynonymsLidex, Fluocinolide, Lyderm, Metosyn, Topsyn, Vanos, Lonide


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    In Vitro

    In vitro activity: Fluocinonide cream has a lower potential to produce atrophic changes of the skin than either clobetasol cream or clobetasol propionate foam. Fluocinonide (Vanos) is a potent glucocorticoid steroid used topically as anti-inflammatory agent for the treatment of skin disorders. Target: Glucocorticoid Receptor Fluocinonide is a potent glucocorticoid steroid used topically as an anti-inflammatory agent for the treatment of skin disorders such as eczema and seborrhoeic dermatitis. Fluocinonide ranks as a 'high-potency' topical corticosteroid. Minimal amounts should be used for a minimal length of time to avoid the occurrence of adverse effects. Fluocinonide should not be used if infection is present. Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs. Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure. 

    In VivoFluocinonide causes prompt and sustains pituitary-adrenocortical suppression in healthy dogs. Fluocinonide results in significant reduction of plasma cortisol and iACTH concentrations by day 2 of treatment in healthy dog, and the lower concentrations continued to day 5. One week after the last application of Fluocinonide, plasma iACTH concentrations in the corticosteroid-treated dogs has returned to the range of values for the control dogs; however, pre- and post-ACTH cortisol concentrations remains suppressed in Fluocinonide treated dogs. Two weeks after the last treatment, the pre-ACTH plasma cortisol concentrations of corticosteroid-treated dogs returns to those of the control dogs, but the post-ACTH plasma cortisol concentrations remains suppressed. 
    Animal modelDogs
    Formulation & Dosage
    ReferencesJ Drugs Dermatol. 2008 Jan;7(1):28-32; J Drugs Dermatol. 2008 Jan;7(1):28-32.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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