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    Fluocinolone Acetonide
    Fluocinolone Acetonide

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1717
    CAS #: 67-73-2Purity ≥98%

    Description: Fluocinolone Acetonide (Flucort-N; Flucinar, Fluonid, Synandone, Jellin, Sinalar) is a topical and synthetic glucocorticoid with with anti-inflammatory and immunomodulating properties. It is used topically in the treatment of various skin disorders. Studies indicate that Fluocinolone Acetonide can inhibit promotion of tumor cells at an early stage of promotion if combined with a promoting agent. In addition, studies suggest that Fluocinolone Acetonide can regulate lipid metabolism by modulating gene expression. Alternate studies show that Fluocinolone Acetonide can inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. 

    References: J Oral Pathol Med. 2006 Mar;35(3):161-6; BMC Med Genomics. 2009 Sep 10;2:58. doi: 10.1186/1755-8794-2-58. 

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    Molecular Weight (MW)452.49
    FormulaC24H30F2O6
    CAS No.67-73-2
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 90 mg/mL (198.89 mM)
    Water: <1 mg/mL
    Ethanol: 12 mg/mL (26.51 mM)
    Other info

    Chemical Name: (1S,2S,4R,8S,9S,11S,12R,13S,19S)-12,19-difluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one

    InChi Key: FEBLZLNTKCEFIT-VSXGLTOVSA-N

    InChi Code: InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1

    SMILES Code: O=C1C=C[[email protected]]2(C)[[email protected]@]3(F)[[email protected]@H](O)C[[email protected]]4(C)[[email protected]]5(C(CO)=O)OC(C)(C)O[[email protected]]5([H])C[[email protected]@]4([H])[[email protected]]3([H])C[[email protected]](F)C2=C1

    SynonymsFlucort-N; Flucinar, Fluonid, Fluocinolone Acetonide, Synandone, Jellin, Sinalar


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    In Vitro

    In vitro activity:  Fluocinolone Acetonide is a synthetic glucocorticoid which acts as an inhibitor of tumor cells. Studies indicate that Fluocinolone Acetonide can inhibit promotion of tumor cells at an early stage of promotion if combined with a promoting agent. In addition, studies suggest that Fluocinolone Acetonide can regulate lipid metabolism by modulating gene expression. Alternate studies show that Fluocinolone Acetonide can inhibit the expression of VEGF (vascular endothelial growth factor) in the retinal pigment epithelial cell line due to its high glucocorticoid receptor affinity. Furthermore, Fluocinolone Acetonide can inhibit TNF-α angiogenesis.

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    References

    J Oral Pathol Med. 2006 Mar;35(3):161-6; BMC Med Genomics. 2009 Sep 10;2:58. doi: 10.1186/1755-8794-2-58.


    These protocols are for reference only. InvivoChem does not independently validate these methods.

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