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    Flumazenil (Ro 15-1788)
    Flumazenil (Ro 15-1788)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1283
    CAS #: 78755-81-4Purity ≥98%

    Description: Flumazenil (Flumazepil, Anexate, Romazicon, Lanexat; Ro-15-1788; Ro-15 1788) is a specific and competitive GABAA receptor antagonist that has been used for the treatment of benzodiazepine overdoses. Flumazenil is a specific benzodiazepine receptor antagonist primarily administered by injection. It is the only benzodiazepine receptor antagonist on the market today. Flumazenil is of benefit in patients who become excessively drowsy after benzodiazepines are used for either diagnostic or therapeutic procedures.

    References: Clin Pharm. 1993 Sep;12(9):641-56; quiz 699-701; Psychopharmacology (Berl). 2000 Jan;148(1):24-32.

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    Molecular Weight (MW)303.29
    FormulaC15H14FN3O3
    CAS No.78755-81-4
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 5 mg/mL (16.5 mM)
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    Other info

    Chemical Name: ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

    InChi Key: OFBIFZUFASYYRE-UHFFFAOYSA-N

    InChi Code: InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3

    SMILES Code: O=C(C1=C(CN2C)N(C=N1)C3=CC=C(F)C=C3C2=O)OCC           

    SynonymsRO 15-1788; Ro 151788; Flumazenil, Flumazepil, Anexate, Romazicon, Lanexat; Ro-15-1788; Ro-15 1788


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    Flumazenil

    Schild plots for flumazenil given at different times before determination of midazolam dose-effect curves. Eur J Pharmacol. 2014 Jan 15; 723: 405–409.
     

    Flumazenil

    Left panel: Effect of flumazenil on pED50 values for midazolam in monkeys that had not received chlordiazepoxide (control; open symbols) and in monkeys that received chlordiazepoxide 46 hr earlier (chlordiazepoxide-treated; filled symbols). Eur J Pharmacol. 2014 Jan 15; 723: 405–409.
     

    Flumazenil

    Time-dependent shifts of the midazolam dose-effect curve produced by different doses of flumazenil. Eur J Pharmacol. 2014 Jan 15; 723: 405–409.


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