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    Fesoterodine Fumarate
    Fesoterodine Fumarate

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    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V1163
    CAS #: 286930-03-8Purity ≥98%

    Description: Fesoterodine Fumarate (SPM907; Toviaz, SPM-907), the fumarate salt of Fesoterodine which is a prodrug of 5-hydroxymethyl tolterodine, is a muscarinic AChR receptor antagonist that has been approved for treating overactive bladder syndrome. 

    References: Curr Med Chem. 2009;16(33):4481-9; BJU Int. 2008 Apr;101(8):1036-42.

    Related CAS #: 286930-02-7 (free base)  

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    Molecular Weight (MW)527.65
    CAS No.286930-03-8
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 100 mg/mL (189.5 mM)
    Water: 100 mg/mL (189.5 mM)
    Ethanol: 100 mg/mL (189.5 mM)
    Other info

    Chemical Name: (E)-but-2-enedioic acid;[2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate


    InChi Code: InChI=1S/C26H37NO3.C4H4O4/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6;5-3(6)1-2-4(7)8/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t23-;/m1./s1

    SMILES Code: O=C(O)/C=C/C(O)=O.CC(C)C(OC1=CC=C(CO)C=C1[[email protected]@H](C2=CC=CC=C2)CCN(C(C)C)C(C)C)=O

    SynonymsSPM-907; SPM907; Fesoterodine, Toviaz, SPM-907

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    In Vitro

    In vitro activity: Fesoterodine is rapidly and extensively converted to 5-HMT, such that the pharmacologic activity appears to be primarily attributable to 5-HMT. Fesoterodine is a competitive antagonist of cholinergic agonist-stimulated responses in human M1-M5 cell lines and has a similar potency and selectivity profile to the radioligand-binding studies. Fesoterodine causes a rightward shift of the concentration-response curve for carbachol with no depression of the maximum in rat bladder strips, and concentration-dependently reduces contractions induced by electrical field stimulation (EFS). Fesoterodine is hydrolyzed by nonspecific esterases to 5-hydroxmethyl tolterodine (5-HMT), which is the active metabolite and is responsible for all its antimuscarinic activity.

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    Curr Med Chem. 2009;16(33):4481-9; BJU Int. 2008 Apr;101(8):1036-42.

    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Fesoterodine Fumarate
    Carbachol CRCs for (a) fesoterodine, SPM 7605, atropine and oxybutynin, and (b) for fesoterodine and SPM 7605 in the presence of neostigmine (5 µm). BJU Int. 2008 Apr;101(8):1036-42. 
    Fesoterodine Fumarate
    CRCs for fesoterodine, SPM7605, atropine, and oxybutynin on contractions induced by EFS. BJU Int. 2008 Apr;101(8):1036-42. 


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