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    Esomeprazole magnesium (S-Omeprazole magnesium)
    Esomeprazole magnesium (S-Omeprazole magnesium)

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    This product is for research use only, not for human use. We do not sell to patients.
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    InvivoChem Cat #: V1635
    CAS #: 161973-10-0Purity ≥98%

    Description: Esomeprazole Magnesium (S-Omeprazole magnesium; Nexium; H 168/68), the magnesium salt of esomeprazole, is S-isomer of omeprazole which is a proton pump inhibitor (PPI) that has been approved for reducing gastric acid secretion (e.g. acid reflux, ulcers). Esomeprazole Magnesium is the magnesium salt of esomeprazole, the S-isomer of omeprazole. In the acidic compartment of parietal cells, esomeprazole is protonated and converted into the active achiral sulphenamide; the active sulphenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen.

    References: Expert Opin Pharmacother. 2003 Feb;4(2):253-64.

    Related CAS#: 95510-70-6 (sodium); 119141-88-7 (S-isomer); 95510-71-7 (potassium); 73590-85-9 (Omeprazole metabolite Omeprazole sulfide; Ufiprazole; Omeprazole sulfide); 88546-55-8 (Omeprazole metabolite Omeprazole sulfone; Omeprazole sulfone; Omeprazole sulphone); 922731-01-9 (Omeprazole D3; H 16868 D3); 73590-58-6 (free form); 161973-10-0 (Esomeprazole magnesium); 217087-09-7 (Esomeprazole Magnesium trihydrate)

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    Molecular Weight (MW)713.12
    CAS No.161973-10-0
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO: 143 mg/mL (200.5 mM)
    Water:<1 mg/mL
    Ethanol: 143 mg/mL (200.5 mM)
    Other info

    Chemical Name: magnesium;5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide


    InChi Code: InChI=1S/2C17H18N3O3S.Mg/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h2*5-8H,9H2,1-4H3;/q2*-1;+2

    SMILES Code: CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC.[Mg+2]          


    Esomeprazole Magnesium; Omeprazole magnesium; Nexium; H 168/68 magnesium

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    In Vitro

    In vitro activity: In several large, double-blind, randomised trials, significantly higher rates of endoscopically-confirmed healing of erosive oesophagitis and resolution of heartburn have been achieved in patients with gastro-oesophageal reflux disease receiving 8 weeks of esomeprazole 40 mg o.d. compared with those receiving omeprazole 20 mg o.d. or lansoprazole 30 mg o.d. In the maintenance of healed erosive oesophagitis, esomeprazole 10, 20 or 40 mg o.d. was significantly more effective than placebo in two 6-month, randomised, double-blind trials. Additionally, esomeprazole 20 mg o.d. was more effective than lansoprazole 15 mg in the maintenance of healed erosive oesophagitis in another 6-month, randomised, double-blind trial. Healing of oesophagitis was also effectively maintained by esomeprazole 40 mg o.d. in a 12-month non-comparative trial. Esomeprazole 20 or 40 mg o.d. effectively relieved heartburn in patients with gastro-oesophageal reflux disease without oesophagitis in two 4-week, placebo-controlled trials. Clinical trials have shown that triple therapy with esomeprazole 40 mg o.d. in combination with amoxicillin and clarithromycin produced Helicobacter pylori eradication rates similar to those obtained using triple therapy involving twice-daily dosing with other proton pump inhibitors. Esomeprazole is well-tolerated, with a spectrum and incidence of adverse events similar to those associated with omeprazole.

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    Expert Opin Pharmacother. 2003 Feb;4(2):253-64.

    These protocols are for reference only. InvivoChem does not independently validate these methods.


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