Size | Price | Stock | Qty |
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25mg |
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50mg |
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100mg |
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250mg |
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Other Sizes |
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Epigoitrin ( (R)-Goitrin; BA-51-090278) is a naturally occurring alkaloid isolated from Isatis indigotica with antiviral, anticancer, and antithyroid activities. Epigoitrin reduces susceptibility to influenza virus via mitochondrial antiviral signaling.
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Molecular Formula |
C5H7NOS
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Molecular Weight |
129.17
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Exact Mass |
129.0248
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Elemental Analysis |
C, 46.49; H, 5.46; N, 10.84; O, 12.39; S, 24.82
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CAS # |
1072-93-1
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Related CAS # |
Goitrin;500-12-9
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Appearance |
Solid powder
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SMILES |
S=C1N([H])C([H])([H])[C@@]([H])(C([H])=C([H])[H])O1
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InChi Key |
UZQVYLOFLQICCT-SCSAIBSYSA-N
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InChi Code |
InChI=1S/C5H7NOS/c1-2-4-3-6-5(8)7-4/h2,4H,1,3H2,(H,6,8)/t4-/m1/s1
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Chemical Name |
2-Oxazolidinethione, 5-vinyl-, (R)-
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Synonyms |
Epigoitrin; (R)-Goitrin; (R) Goitrin; BA-51-090278; BA 51-090278; BA 51 090278; BA 51090278; BA51090278
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HS Tariff Code |
2934.99.9001
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Storage |
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Solubility (In Vitro) |
DMSO : ~50 mg/mL (~387.06 mM)
Ethanol : ~3.33 mg/mL (~25.78 mM) |
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Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (19.35 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: 2.5 mg/mL (19.35 mM) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), suspension solution; with ultrasonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C,1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. View More
Solubility in Formulation 3: ≥ 2.5 mg/mL (19.35 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. Solubility in Formulation 4: 10% DMSO+40% PEG300+5% Tween-80+45% Saline: ≥ 2.5 mg/mL (19.35 mM) |
Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
1 mM | 7.7417 mL | 38.7087 mL | 77.4174 mL | |
5 mM | 1.5483 mL | 7.7417 mL | 15.4835 mL | |
10 mM | 0.7742 mL | 3.8709 mL | 7.7417 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.
Calculation results
Working concentration: mg/mL;
Method for preparing DMSO stock solution: mg drug pre-dissolved in μL DMSO (stock solution concentration mg/mL). Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation::Take μL DMSO stock solution, next add μL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O,mix and clarify.
(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.
Epigoitrin attenuated the morbidity and mortality caused by influenza infection in stressed mice.[1]. Front Pharmacol. 2019 Feb 7;10:78. td> |
Epigoitrin protected against pneumonia caused by influenza infection in stressed mice. [1]. Front Pharmacol. 2019 Feb 7;10:78. td> |
Epigoitrin improved MAVS antiviral signaling after influenza infection in stressed mice.[1] .Front Pharmacol. 2019 Feb 7;10:78. td> |
Epigoitrin reduced H1N1 viral expression in corticosterone-loaded A549 cell. [1]. Front Pharmacol. 2019 Feb 7;10:78. td> |
Epigoitrin inhibited H1N1 replication and promoted IFN-β generation after influenza infection in stress cell model.[1]. Front Pharmacol. 2019 Feb 7;10:78. td> |
MFN2 was involved in the regulation of IFN-β production by epigoitrin in stress cell model. [1]. Front Pharmacol. 2019 Feb 7;10:78. td> |
Schematic diagram of the mechanism of Epigoitrin-induced attenuation of H1N1 pathogenesis in the susceptible model.[1]. Front Pharmacol. 2019 Feb 7;10:78. td> |