My cart
In the shopping cart is not goods, to choose and buy!
  • Product Name
  • Size
  • Quantity
  • Amount
    Selected items : 0 pieces Total : CHECK OUT()
    Ebselen
    Ebselen

    Price:
    Market Price:

    This product is for research use only, not for human use. We do not sell to patients.
    Number: - + Pieces(InventoryPieces)
    InvivoChem Cat #: V2837
    CAS #: 60940-34-3 Purity ≥98%

    Description: Ebselen (also known as SPI-1005), is an organoselenium and small molecule compound with potential anti-oxidant, anti-inflammatory and cytoprotective activity. It is a capsid inhibitor of HIV-1 replication. Upon oral administration, Ebselen mimics the activity of glutathione peroxidase (GPx) and can utilize glutathione to reduce other unstable molecules, thus preventing the formation of reactive oxygen species (ROS) and reducing oxidative stress on the cell. In the cochlea, this agent may prevent drug-induced injury to the auditory hair cells thereby preventing hearing loss. GPx is the main antioxidant enzyme in the cochlea and protects the inner ear from loud sounds and biochemical damage. In addition, ebselen is able to inhibit the activity of many enzymes involved in inflammation.

    References:  2016 Mar 25;60(4):2195-208. 2013;4:1332.

    Customer Validation
    Official Supplier of
    • VE
    • OF
    • YALE
    • hhmi
    • 香港大学
    Related Products
    Publications Citing InvivoChem Products
    • Physicochemical and Storage Information
    • Protocol
    • Quality Control Documentation
    • Related Biological Data
    • Customer Review
    Molecular Weight (MW) 274.18 
    Formula C₁₃H₉NOSe
    CAS No. 60940-34-3
    Storage-20℃ for 3 years in powder form
    -80℃ for 2 years in solvent
    Solubility (In vitro)DMSO:10 mM 
    Water: <1 mg/mL
    Ethanol: <1 mg/mL
    SMILES Code O=C1N(C2=CC=CC=C2)[Se]C3=CC=CC=C13
    Synonyms SPI-1005; SPI1005; SPI 1005; PZ 51; PZ51; PZ-51; DR3305; DR 3305; DR-3305; CCG 39161; CCG39161; CCG-39161


    • Molarity Calculator
    • Dilution Calculator
    • The molarity calculator equation

      Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

      • Mass
      • Concentration
      • Volume
      • Molecular Weight *
      • =
      • ×
      • ×
    • The dilution calculator equation

      Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

      This equation is commonly abbreviated as: C1V1 = C2V2

      • Concentration (start)
      • ×
      • Volume (start)
      • =
      • Concentration (final)
      • ×
      • Volume (final)
      • ×
      • =
      • ×
      • C1
      •  
      • V1
      •  
      • C2
      •  
      • V2
    In Vitro

    In vitro activity: Ebselen is a small-molecule capsid Inhibitor of HIV-1 replication. Ebselen is an organoselenium compound, as an inhibitor of HIV-1 capsid CTD dimerization. Ebselen inhibits early viral postentry events of the HIV-1 life cycle by impairing the incoming capsid uncoating process. Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase). Ebselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain. 


    Kinase Assay: Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties. Ebselen is an inhibitor of inositol monophosphatase (IMPase).

    In VivoEbselen permeates the blood-brain barrier and inhibits endogenous inositol monophosphatase in mouse brain.
    Animal modelMouse
    Formulation & DosageN/A
    References  2016 Mar 25;60(4):2195-208. 


    These protocols are for reference only. InvivoChem does not independently validate these methods.

    Ebselen


    Ebselen induces local structural changes in CA-CTD.  2016 Mar 25;60(4):2195-208.

    Ebselen


    Residues affected by ebselen in 15N–labeled CA-CTD.  2016 Mar 25;60(4):2195-208.

     Ebselen


    Mechanism of action of Ebselen.  2016 Mar 25;60(4):2195-208.


    评论

      Home Prev Next Last page / pices

      发评论

      ×
      Your information is safe with us. * Required Fields.
      Products are for research use only;  We do not sell to patients
      Tel: 1-708-310-1919
      Fax: 1-708-557-7486
      Subscribe to our E-newsletter
      • Name*
      • *
      • E-mail*
      • *
      • instructions:
      • *
      Copyright 2020 InvivoChem LLC | All Rights Reserved
      prompt
      Do you confirm the receipt?